id: Pfam:PF20173
pfam_id: PF20173
name: RZ type zinc finger domain
short_name: ZnF_RZ-type
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20173
counters:
  proteins: 4869
  matches: 4880
  proteomes: 2015
  taxa: 5628
  structures: 11
  alphafold_models: 895
  domain_architectures: 272
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046439
description: This entry represents the RZ type zinc finger domain, found in NFX1-type zinc finger-containing
  protein 1 (ZNFX1) and E3 ubiquitin-protein ligase RNF213 from humans. It contains two conserved histidine
  residues and four conserved cysteine residues in a CHC3H motif. It can bind divalent transition metals,
  with a preference for Zn2+. ZNFX1 is an RNA-binding protein that initiates the antiviral response and
  is required to restrict the replication of RNA viruses [[cite:PUB00100916],[cite:PUB00100918]]. RNF213
  is a giant E3 ubiquitin ligase that can catalyse ubiquitination of both proteins and lipids, which is
  involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity.
  It functions as a key immune sensor by catalysing ubiquitination of the lipid A moiety of bacterial
  LPS via its RZ-type zinc-finger and restricts the proliferation of cytosolic bacteria [[cite:PUB00100919],[cite:PUB00100915]].
  RNF213 is a major susceptibility factor of Moyamoya disease [[cite:PUB00100917]].