id: Pfam:PF20178
pfam_id: PF20178
name: Dermonecrotic toxin, N-terminal domain
short_name: ToxA_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20178
counters:
  proteins: 2773
  matches: 3160
  proteomes: 355
  taxa: 512
  structures: 2
  alphafold_models: 314
  domain_architectures: 67
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046673
description: This entry represents the N-terminal domain of bacterial proteins, such as the dermonecreotic
  toxin (ToxA) from Pasteurella multocida, an osteolytic toxin that induces bone resorption. It is a potent
  mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis a major
  respiratory disease in pigs. This domain contributes to the membrane localisation of its C-terminal
  domains [[cite:PUB00040389]].