id: Pfam:PF20235
pfam_id: PF20235
name: PIR2-like, helical domain
short_name: PIR2-like_helical
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20235
counters:
  proteins: 3036
  matches: 3844
  proteomes: 373
  taxa: 1007
  structures: 0
  alphafold_models: 2578
  domain_architectures: 64
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046527
description: This helical domain is found at the N-terminal of plant E3-ligase proteins, including PP2CA
  INTERACTING RING FINGER PROTEIN 2 (PIR2, also known as MND1-interacting protein 1) and its paralogues
  RF4 and RF298 from Arabidopsis. The function of this domain is unknown. PIR2 is the closest homologue
  of PIR1 (PP2CA interacting RING finger protein 1) and both positively modulate ABA signaling by targeting
  PP2CA for degradation [[cite:PUB00101279]].