id: Pfam:PF20254
pfam_id: PF20254
name: N,N-dimethylformamidase beta subunit-like, C-terminal
short_name: DMFA2_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20254
counters:
  proteins: 4303
  matches: 4320
  proteomes: 2858
  taxa: 4293
  structures: 9
  alphafold_models: 2159
  domain_architectures: 234
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046540
description: This entry represents a domain found at the C-terminal of bacterial proteins, including N,N-dimethylformamidase
  beta (DMFA2) subunit from Paracoccus [[cite:PUB00101281]], the large subunit of dimethylformamidase
  (DMFase), an enzyme containing a Fe+3 ion in the active site that catalyses the hydrolytic cleavage
  of the amide bond in N,N-dimethyl formamide. This domain is described as domain III, which adopts an
  alpha/beta/alpha fold, with five beta-strands that are parallel and sandwiched between alpha-helices.
  This domain is also found in some uncharacterised fungal sequences.