id: Pfam:PF20416
pfam_id: PF20416
name: U3 small nucleolar RNA-associated protein 20 domain
short_name: UTP20
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20416
counters:
  proteins: 3725
  matches: 3767
  proteomes: 3019
  taxa: 8023
  structures: 41
  alphafold_models: 200
  domain_architectures: 77
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046523
description: This domain is found towards the C-terminal the U3 small nucleolar RNA-associated protein
  20 (UTP20) from yeast and its human homologue, also known as DRIM (Down-Regulated In Metastasis). DRIM
  is differentially expressed in metastatic and non-metastatic human breast carcinoma cells [[cite:PUB00014724]].
  Proteins of this entry are involved in processing of non-coding RNA as components of the small-subunit
  (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA [[cite:PUB00014725],[cite:PUB00101284]].
  UTP20 is a huge alpha-solenoid that functions as a scaffold [[cite:PUB00101286],[cite:PUB00101285]].