id: Pfam:PF20661
pfam_id: PF20661
name: SutA RNAP-binding domain
short_name: SutA-RBD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20661
counters:
  proteins: 1448
  matches: 1448
  proteomes: 819
  taxa: 1076
  structures: 3
  alphafold_models: 879
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR049191
description: This domain (previously known as DUF6813) is found in the transcriptional regulator SutA
  from Pseudomonas aeruginosa and similar proteins mainly from Gammaproteobacteria. In Pseudomonas aeruginosa,
  SutA adapts bacteria to hypoxia and nutrition-limited environment during chronic infection by increasing
  transcriptional activity of an RNA polymerase (RNAP) holoenzyme. SutA interacts directly with RNAP holoenzyme
  and the RNAP-beta protrusion is its primary anchor site. This domain comprises an alpha-helix and a
  beta-strand and is responsible for interaction with RNAP-beta protrusion [[cite:PUB00152756]]. It contains
  a conserved FLxxGG sequence motif that appears to be located near the C-terminal helix cap. The SutA-RBD
  alpha-helix binds to a hydrophobic groove on RNAP-beta protrusion [[cite:PUB00152756]].