id: Pfam:PF22046
pfam_id: PF22046
name: Enoyl-acyl carrier protein reductase FabMG
short_name: FabMG
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF22046
counters:
  proteins: 237
  matches: 237
  proteomes: 231
  taxa: 393
  structures: 2
  alphafold_models: 135
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR053909
description: This entry, previously known as DUF6936, represents FabMG enoyl-acyl carrier protein reductase
  (ENR) and related proteins. This enzyme is a FabI-type ENR that employs NADH as a coenzyme and mediates
  resistance to triclosan. FabMG adopts an alpha/beta structure, with a central parallel beta-sheet elaborated
  with alpha-helices on both sides. FabMG differs from other related ENRs in sequence and structure. These
  differences, in particular in the substrate-binding loop and pocket regions in which triclosan binds,
  could be responsible for the triclosan resistance [[cite:PUB00154385]].