id: Pfam:PF22397
pfam_id: PF22397
name: DarT1-associated NADAR antitoxin
short_name: NADAR-DarT1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF22397
counters:
  proteins: 250
  matches: 250
  proteomes: 244
  taxa: 629
  structures: 1
  alphafold_models: 153
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR053913
description: This entry, previously known as DUF6977, represents the DarT1-associated NADAR antitoxin
  and related proteins. The DarT-NADAR system is a TA system catalysing the specific and reversible ADP-ribosylation
  of guanosine bases in which DarT1-associated NADARs reverse guanine ADP-ribosylation catalysed by DarT1.
  DarT1-associated NADAR antitoxin adopts an alpha/beta globular structure characterised by an alpha-helical
  core that forms the active site flanked by two small beta sheet regions, comprising two and three strands
  [[cite:PUB00154386]]. Its structural core is globally similar to the structure of E.coli protein YbiA,
  a member of the NADAR domain family.