id: Pfam:PF22507
pfam_id: PF22507
name: Family of unknown function (DUF6994)
short_name: DUF6994
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF22507
counters:
  proteins: 203
  matches: 203
  proteomes: 178
  taxa: 462
  structures: 0
  alphafold_models: 129
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR054263
description: This is a family of uncharacterised bacterial proteins. They are probably remotely related
  to His-Me finger endonucleases. The conservation of the putative active site residues in this family
  is not strict, in particular the position of the catalytic histidine. The residues involved in metal
  coordination are conserved. The presence in the vicinity of two invariant aspartate residues that point
  toward the putative active site suggests that these proteins may still function as enzymes but probably
  via a somewhat different catalytic mechanism. They may still retain their catalytic activity by employing
  these conserved aspartates that in the predicted AF2 models are well positioned to undertake a role
  in a potential nucleophilic attack.