id: Pfam:PF22833
pfam_id: PF22833
name: C5orf34-like, second domain
short_name: C5orf34_2nd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF22833
counters:
  proteins: 635
  matches: 650
  proteomes: 468
  taxa: 1675
  structures: 0
  alphafold_models: 533
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR053899
description: This entry represents a domain located C-terminal to [pfam:PF15025] in a family of eukaryotic
  proteins, including the human uncharacterised protein C5orf34, which has been reported to be correlated
  with an unfavourable prognosis of patients from a variety of human malignancies [[cite:PUB00154384]].
  This domain is predicted to show an alpha-beta structure with high structural similarity to a polo box
  [[cite:PUB00152793]].