id: Pfam:PF23859
pfam_id: PF23859
name: DeoxyPurine in DNA protein A
short_name: DpdA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF23859
counters:
  proteins: 468
  matches: 479
  proteomes: 394
  taxa: 733
  structures: 0
  alphafold_models: 270
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR055645
description: This entry represents the DpdA family of proteins, which are involved in the insertion of
  deazapurine modifications in bacterial and phage DNA. DpdA proteins are paralogues of tRNA-guanine transglycosylases
  (TGT), but have evolved to act on DNA rather than RNA. They catalyze the incorporation of 7-deazaguanine
  derivatives such as dADG (7-amido-7- deazaguanine) and dpreQ0 (7-cyano-7-deazaguanine) into DNA, which
  is thought to function as a protection mechanism against endonucleases. The dpdA gene is typically part
  of a genomic island, along with dpdB, dpdC and dpdD genes, and is proposed to be part of a restriction/
  modification system that protects bacteria from foreign DNA.