id: Pfam:PF23926
pfam_id: PF23926
name: LtfC-like, beta-sandwich domain
short_name: LtfC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF23926
counters:
  proteins: 522
  matches: 536
  proteomes: 498
  taxa: 1092
  structures: 7
  alphafold_models: 59
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR055688
description: This entry, previously known as DUF7264, represents a domain found in the Minor tail protein
  Gp6, Collar protein p132, Lateral tail fiber protein C (LtfC) and related phage proteins. This domain
  folds into a beta-sandwich fold with and extended beta-hairpin that projects away from it. The minor
  tail proteins Gp6 are likely involved in the assembly or function of the tail structure in bacteriophages.
  The collar protein p132 forms the T5 phage collar structure, which serves as an anchoring point for
  the side tail fiber protein pb1, suggesting a role in stabilising the tail fibers and ensuring proper
  attachment to the host cell [[cite:PUB00155631]]. The lateral tail fiber protein C (LtfC) is a component
  of the DT57C bacteriophage tail tip complex where it forms a dodecameric ring [[cite:PUB00155646]].
  LtfC adopts a compact, single-domain structure. The LtfC ring is complemented by another lateral tail
  fiber protein, LtfA. Each of the LtfA monomers is connected to the LtfC assembly in a unique way by
  augmenting the edges of LtfC beta-sheets with two short beta-strands and thus completing the LtfC beta-sandwich
  structure.