id: Pfam:PF24674
pfam_id: PF24674
name: SNTX, MACPF/CDC-like domain
short_name: MACPF_SNTX
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF24674
counters:
  proteins: 2236
  matches: 2256
  proteomes: 534
  taxa: 1702
  structures: 1
  alphafold_models: 1831
  domain_architectures: 175
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR056072
description: This MACPF/CDC-like domain is found N-terminal in a number of toxins including Stonustoxin
  (SNTX), Neoverrucotoxin (NeoVTX), Verrucotoxin (VTX), Sp-CTx and related proteins. This domain is a
  pore-forming domain and is involved in the formation of large ring-shaped pores in rat erythrocyte membranes
  [[cite:PUB00091171]]. The formation of MACPF/CDC-like pores is probably central to the toxin's hemolytic
  activity, and cell lysis could explain physiological effects, including edema, increased vascular permeability,
  and muscle damage.