id: Pfam:PF24929
pfam_id: PF24929
name: GlfB-like, C-terminal domain
short_name: GlfB_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF24929
counters:
  proteins: 107
  matches: 114
  proteomes: 28
  taxa: 127
  structures: 0
  alphafold_models: 89
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR056651
description: This domain is found at the C-terminal of Ras guanine nucleotide exchange factor glfB from
  Dictyostelium discoideum and in similar uncharacterised proteins from lower eukaryotes. GflB is a GpaB-activated,
  rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between
  Ras and Rap signalling at the leading edge of chemotaxing cells [[cite:PUB00159973],[cite:PUB00159975]].
  This protein also acts as a key regulator of antin -driven membrane protrusions during processes such
  as phagocytosis and cytokinesis, possibly by modulating rapA signalling pathways [[cite:PUB00159974]].
  This domain is predicted to adopt a globular a/b structure.