id: Pfam:PF25227
pfam_id: PF25227
name: Domain of unknown function (DUF7845)
short_name: DUF7845
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25227
counters:
  proteins: 289
  matches: 291
  proteomes: 194
  taxa: 350
  structures: 0
  alphafold_models: 251
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR057167
description: This entry represents a domain of unknown function. In some proteins the is a C-terminal
  HTH domain that presumably binds to DNA. This domain may bind to an as unyet identified ligand to enable
  regulation of bacterial genes. This domain contains a large beta sheet composed of 11 beta strands with
  helices packed on the convex face. There is some evidence from structure prediction that this domain
  may dimerise and form a large structure that has a large hole through it that might accommodate DNA.