id: Pfam:PF25367
pfam_id: PF25367
name: Domain of unknown function (DUF7883)
short_name: DUF7883
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25367
counters:
  proteins: 27
  matches: 27
  proteomes: 27
  taxa: 62
  structures: 0
  alphafold_models: 26
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR057205
description: This entry represents a domain of unknown function (DUF) identified in Trypanosoma. Based
  on structural predictions, this domain is hypothesised to adopt a winged helix-turn-helix (HTH) fold.
  Winged helix DNA-binding proteins share a characteristic winged helix-turn-helix DNA-binding motif,
  in which the "wings", or loops, are small beta-sheets [[cite:PUB00013195]].