id: Pfam:PF25372
pfam_id: PF25372
name: F-box/LRR-repeat protein 15, leucine rich repeat domain
short_name: LRR_FBXL15
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25372
counters:
  proteins: 30220
  matches: 38539
  proteomes: 3479
  taxa: 9284
  structures: 9
  alphafold_models: 24573
  domain_architectures: 1075
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR057207
description: This domain represents a set of tandem leucine rich repeats found in human F-box/LRR-repeat
  protein 15 (FBXL15) and similar eukaryotic proteins. FBXL15 is the substrate recognition component of
  a SCF (SKP1-CUL1-F-box protein), an E3 ubiquitin-protein ligase complex which mediates the ubiquitination
  and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP
  signalling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance [[cite:PUB00147666]].