id: Pfam:PF25453
pfam_id: PF25453
name: Domain of unknown function (DUF7898)
short_name: DUF7898
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25453
counters:
  proteins: 1405
  matches: 1406
  proteomes: 1148
  taxa: 2960
  structures: 17
  alphafold_models: 624
  domain_architectures: 52
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR057220
description: This entry describes the N-terminal domain of unknown function of DNA polymerase theta subunit
  (PolQ) majoritarily from fungal and and yeast proteins. Structural predictions suggest that this family
  adopts Helix-Helix-Helix (HHH) motifs. Proteins containing HHH motifs are typically associated with
  DNA-binding functions. These structural elements are often found in enzymes involved in DNA metabolism,
  such as DNA polymerases and helicases [[cite:PUB00101275],[cite:PUB00021052]].