id: Pfam:PF25637
pfam_id: PF25637
name: Family of unknown function (DUF7942)
short_name: DUF7942
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25637
counters:
  proteins: 608
  matches: 654
  proteomes: 487
  taxa: 641
  structures: 0
  alphafold_models: 245
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR057702
description: This family of uncharacterised bacterial proteins is found mainly in Actinomycetes. Members
  of this family are predicted to contain three transmembrane helices. A member of this family, SCO4225,
  is a putative integral membrane protein found in Streptomyces coelicolor, [swissprot:Q9FCE5]. The gene
  encoding SCO4225 is part of a cluster of genes (phoU to sco4225) that are involved in phosphate regulation
  and metabolism. This gene cluster is regulated by the two-component system PhoR-PhoP, which responds
  to phosphate availability in the environment [[cite:PUB00159567]]. The expression of SCO4225 is directly
  regulated by MacR, a response regulator that binds to a specific sequence in the promoter region of
  SCO4225. This regulation links SCO4225 to other genes in the MacR regulon, many of which are also membrane
  proteins [[cite:PUB00159414]].