id: Pfam:PF25752
pfam_id: PF25752
name: N-terminal domain of DUF1619
short_name: DUF1619_N
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25752
counters:
  proteins: 3088
  matches: 3095
  proteomes: 1178
  taxa: 3947
  structures: 0
  alphafold_models: 2636
  domain_architectures: 41
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR057724
description: This is domain is found N-terminal in tectonic proteins (TCTN1/2/3) It contains a number
  of conserved cysteine residues predicted to form disulfide bonds. Although function of this domain is
  currently unknown, studies on TCTN2 suggest that it is indispensable for its functions [[cite:PUB00097826],[cite:PUB00097827]].
  TCTN1, TCTN2, and TCTN3 are members of the tectonic protein family that play crucial roles in ciliogenesis
  and ciliary function. While they share some common functions, each protein also has specific roles in
  the process of cilia formation and maintenance. These proteins interact with several other ciliopathy
  proteins, forming a complex known as the Tectonic ciliopathy complex. This complex is required for hedgehog
  signalling transduction and regulation of ciliary membrane composition [[cite:PUB00069722],[cite:PUB00160606]].