id: Pfam:PF26224
pfam_id: PF26224
name: Domain of unknown function (DUF8050)
short_name: DUF8050
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26224
counters:
  proteins: 186
  matches: 186
  proteomes: 186
  taxa: 291
  structures: 0
  alphafold_models: 175
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR058363
description: Members of this integral membrane protein family are found exclusively in halophilic archaea.
  In at least three species (Haloarcula marismortui, Haloquadratum walsbyi, and Haloferax volcanii), members
  are found in the gene neighbourhood of archaeosortase A, suggesting a role in protein sorting. Structure
  prediction show these proteins have four likely transmembrane helices, with a four stranded beta meander
  inserted between helices one and two. The structure of this domain shows significant structural similarity
  to claudin proteins. This suggests that these proteins may be accessory components of an as yet unidentified
  membrane complex.