id: Pfam:PF26988
pfam_id: PF26988
name: Domain of unknown function (DUF8314)
short_name: DUF8314
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26988
counters:
  proteins: 183
  matches: 183
  proteomes: 175
  taxa: 420
  structures: 0
  alphafold_models: 63
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059358
description: This entry represents a domain of unknown function in putative Ras GEF and other uncharacterised
  proteins mostly found in fungi. This domain belongs to proteins with a conserved four or five- helix
  up-and-down bundle structure. This structure is typical of focal adhesion targeting (FAT) domains and
  is responsible for dimerisation. These proteins are also present in transcriptional regulators where
  the bundle structure is important for their dynamic conformational equilibrium to control target specificity.
  The conserved helical bundle architecture enables these proteins to function in protein- protein interactions
  and regulatory processes [[cite:PUB00075415],[cite:PUB00004911],[cite:PUB00161916]].