id: Pfam:PF26990
pfam_id: PF26990
name: Domain of unknown function (DUF8316)
short_name: DUF8316
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26990
counters:
  proteins: 467
  matches: 468
  proteomes: 338
  taxa: 391
  structures: 0
  alphafold_models: 251
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059360
description: This entry represents a domain of unknown function at the N-terminal in putative histidine
  kinases mostly found in bacteria. This domain belongs to proteins with a conserved four or five- helix
  up-and-down bundle structure. This structure is typical of focal adhesion targeting (FAT) domains and
  is responsible for dimerisation. It could also be present in transcriptional regulators where the bundle
  structure is important for their dynamic conformational equilibrium to control target specificity. The
  conserved helical bundle architecture enables these proteins to function in protein- protein interactions
  and regulatory processes [[cite:PUB00075415],[cite:PUB00004911],[cite:PUB00161916]].