id: Pfam:PF26992
pfam_id: PF26992
name: Domain of unknown function (DUF8318)
short_name: DUF8318
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26992
counters:
  proteins: 2517
  matches: 2519
  proteomes: 1779
  taxa: 2159
  structures: 0
  alphafold_models: 1346
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059362
description: This entry represents the domain of unknown function at the N-terminal domain in putative
  histidine kinases mostly found in bacteria. This domain (VBS) belongs to proteins with a conserved four
  or five- helix up-and-down bundle structure. This structure is typical of focal adhesion targeting (FAT)
  domains and is responsible for dimerisation. These proteins are also present in transcriptional regulators
  where the bundle structure is important for their dynamic conformational equilibrium to control target
  specificity. The conserved helical bundle architecture enables these proteins to function in protein-protein
  interactions and regulatory processes [[cite:PUB00075415],[cite:PUB00004911],[cite:PUB00161916]]. This
  domain is usually find associated with [pfam:PF07730].