id: Pfam:PF26994
pfam_id: PF26994
name: Domain of unknown function (DUF8320)
short_name: DUF8320
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26994
counters:
  proteins: 706
  matches: 706
  proteomes: 491
  taxa: 637
  structures: 0
  alphafold_models: 415
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059364
description: This entry represents a domain of unknown function at the N-terminal in uncharacterised proteins
  mostly found in bacteria. This domain belongs to proteins with a conserved four or five-helix up-and-down
  bundle structure. This structure is typical of focal adhesion targeting (FAT) domains and is responsible
  for dimerisation. These proteins are also present in transcriptional regulators where the bundle structure
  is important for their dynamic conformational equilibrium to control target specificity. The conserved
  helical bundle architecture enables these proteins to function in protein-protein interactions and regulatory
  processes [[cite:PUB00075415],[cite:PUB00004911],[cite:PUB00161916]].