id: Pfam:PF26998
pfam_id: PF26998
name: Domain of unknown function (DUF8323)
short_name: DUF8323
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26998
counters:
  proteins: 25
  matches: 25
  proteomes: 22
  taxa: 67
  structures: 0
  alphafold_models: 10
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059367
description: This entry represents a domain of unknown function in a small group of proteins mostly found
  in animals , particularly nematodes. This domain contains a Spectrin fold with a conserved three-helix
  bundle structure that is typically arranged in tandem repeats. These repeats confer mechanical flexibility
  and structural resilience, allowing the proteins to maintain cell shape and organisation. Spectrin-repeat
  proteins form elongated scaffolds beneath the plasma membrane and contribute to cytoskeletal integrity
  and membrane stability [[cite:PUB00161917]]. This domain can be found associated with [pfam:PF00307].