id: Pfam:PF27005
pfam_id: PF27005
name: Domain of unknown function (DUF8326)
short_name: DUF8326
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF27005
counters:
  proteins: 126
  matches: 126
  proteomes: 87
  taxa: 206
  structures: 0
  alphafold_models: 47
  domain_architectures: 29
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059370
description: This entry represents a domain of unknown function in putative Ig-domain-containing proteins
  mainly from animals. This domain contains a Spectrin fold with a conserved three-helix bundle structure
  that is typically arranged in tandem repeats. These repeats confer mechanical flexibility and structural
  resilience, allowing the proteins to maintain cell shape and organisation. Spectrin-repeat proteins
  form elongated scaffolds beneath the plasma membrane and contribute to cytoskeletal integrity and membrane
  stability [[cite:PUB00161917]].