id: Pfam:PF27014
pfam_id: PF27014
name: Domain of unknown function (DUF8334)
short_name: DUF8334
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF27014
counters:
  proteins: 22
  matches: 22
  proteomes: 22
  taxa: 46
  structures: 0
  alphafold_models: 2
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059378
description: This entry represents a domain of unknown function in uncharacterised proteins mostly found
  in Sar organisms. These proteins contain a SNARE-like fold. They are characterised by their tetrameric
  coiled-coil structures that facilitate membrane fusion processes. SNARE proteins are present in synaptic
  terminals, endoplasmic reticulum, and Golgi apparatus where the coiled-coil structure is important for
  membrane targeting and fusion specificity. The conserved coiled-coil architecture enables these proteins
  to function in vesicle trafficking and membrane fusion events [[cite:PUB00161918]].