id: Pfam:PF27019
pfam_id: PF27019
name: Domain of unknown function (DUF8335)
short_name: DUF8335
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF27019
counters:
  proteins: 148
  matches: 151
  proteomes: 143
  taxa: 305
  structures: 0
  alphafold_models: 127
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059379
description: This entry represents a domain of unknown function in putative TLC domain-containing and
  other uncharacterised proteins mostly found in fungi. These proteins contain a SNARE-like fold. They
  are characterised by their tetrameric coiled-coil structures that facilitate membrane fusion processes.
  SNARE proteins are present in synaptic terminals, endoplasmic reticulum, and Golgi apparatus where the
  coiled-coil structure is important for membrane targeting and fusion specificity. The conserved coiled-coil
  architecture enables these proteins to function in vesicle trafficking and membrane fusion events [[cite:PUB00161918]].