id: Pfam:PF28130
pfam_id: PF28130
name: Domain of unknown function (DUF8371)
short_name: DUF8371
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF28130
counters:
  proteins: 570
  matches: 570
  proteomes: 504
  taxa: 1264
  structures: 0
  alphafold_models: 334
  domain_architectures: 12
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR059415
description: This domain is found in uncharacterised bacterial proteins. It is predicted to fold into
  an alpha/beta structure composed of a central five-stranded mixed beta-sheet and alpha-helices packed
  on both sides. This domain has a significant structural similarity to domains members of PD-(D/E)XK
  nuclease superfamily that extends to the active site architecture suggesting that this domain may possess
  endonuclease activity. This domain is frequently found in combination with [pfam:PF28123] (DUF8370).