id: Pfam:PF28608
pfam_id: PF28608
name: Family of unknown function (DUF8443)
short_name: DUF8443
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF28608
counters:
  proteins: 2103
  matches: 2104
  proteomes: 1778
  taxa: 2473
  structures: 0
  alphafold_models: 1415
  domain_architectures: 11
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR061513
description: This entry represents a conserved domain found at the C-terminus of S41 family carboxyl-terminal
  processing peptidases in members of the phylum Bacteroidota. The domain is approximately 85-90 amino
  acids in length and is located immediately downstream of the Peptidase_S41 catalytic domain ([pfam:PF03572]).
  S41 family peptidases are serine proteases involved in C-terminal processing of proteins, including
  the removal of C-terminal extensions from penicillin-binding proteins and other substrates. This C-terminal
  domain is found exclusively in Bacteroidota, particularly in the classes Bacteroidia, Flavobacteriia,
  Cytophagia and Sphingobacteriia, suggesting it may confer phylum-specific functionality or substrate
  specificity. The domain architecture of these proteins typically consists of an N-terminal CtpB_N-like
  domain ([pfam:PF22694]), one or more PDZ domains ([pfam:PF00595], [pfam:PF13180], [pfam:PF17820]), the
  catalytic Peptidase_S41 domain, and this C-terminal domain. The function of this domain remains to be
  determined.