id: Pfam:PF28776
pfam_id: PF28776
name: Domain of unknown function (DUF8459)
short_name: DUF8459
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF28776
counters:
  proteins: 1367
  matches: 1367
  proteomes: 1025
  taxa: 1991
  structures: 0
  alphafold_models: 850
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR061529
description: This entry represents a domain of unknown function found in diverse proteins across Bacteria.
  The domain is around 95-100 residues in length and is found in mechanosensitive channel proteins, where
  it is located N-terminal to the mechanosensitive channel second transmembrane helix domain ([pfam:PF00924]),
  and in endolytic peptidoglycan transglycosylases such as RlpA, where it precedes the double-psi beta-barrel
  domain ([pfam:PF03330]). The domain is found across Cyanobacteriota, Bacteroidota and Pseudomonadota.
  The function of this domain remains to be determined.