id: Pfam:PF29210
pfam_id: PF29210
name: Domain of unknown function (DUF8512)
short_name: DUF8512
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF29210
counters:
  proteins: 226
  matches: 226
  proteomes: 122
  taxa: 234
  structures: 0
  alphafold_models: 158
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR061582
description: This entry represents a C-terminal domain of approximately 40 residues found in anti-sigma
  factor antagonist proteins from spirochaetes, predominantly from Treponema and Leptospira species. The
  domain contains conserved cysteine residues in a CPIC...CSEC motif, suggesting potential metal binding.
  Anti-sigma factor antagonist proteins regulate sigma factor activity in bacterial stress responses.
  The protein TP0233 from Treponema pallidum has been shown to interact with flagellar motor components
  [[cite:PUB00163734]]. The specific function of this domain remains to be determined.