id: Pfam:PF30500
pfam_id: PF30500
name: DUF3084-associated C-terminal helical hairpin
short_name: DUF3084_C
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF30500
counters:
  proteins: 334
  matches: 334
  proteomes: 330
  taxa: 873
  structures: 0
  alphafold_models: 209
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR062273
description: This entry represents a C-terminal helical hairpin domain found in DUF3084-containing membrane
  proteins. It follows the N-terminal DUF3084 domain ([pfam:PF11283]) and one or more intervening domains.
  The proteins contain an N-terminal signal peptide and a transmembrane helix, suggesting membrane localisation.
  In Nostoc sp. PCC 7120, the protein Alr4393 is predicted to be a single-pass membrane protein. In Synechococcus
  sp. WH 8102, the homologue SYNW0274 has been computationally linked to the nitrogen assimilation regulatory
  network controlled by NtcA. The family is found predominantly in Cyanobacteria (Nostocales, Oscillatoriales)
  and in Negativicutes (Veillonellaceae). The function of this domain remains to be determined.