4-Hydroxyphenyl acetic acid

Ontology mapping

Primary identifier: CHEBI:18101
Ontology label: 4-hydroxyphenylacetic acid
kg-microbe node: CHEBI:18101

Nutritional roles

Role
CARBON_SOURCE
Confidence
0.6
Evidence
- Reference type
  COMPUTATIONAL_PREDICTION
  Reference text
  Assigned by in-session Claude reasoning (no external API)
  Curator note
  Provisional in-session LLM role assignment; review recommended.

Synonyms (3)

Synonym	Type	Source
4-Hydroxyphenylacetate	EXACT	CHEBI
(4-hydroxyphenyl)acetic acid	EXACT	CHEBI
(p-hydroxyphenyl)acetic acid	EXACT	CHEBI

Rejected enrichment labels (2)

Provenance-only candidates: these are not synonyms and do not resolve to this record.

Rejected label	Disposition	Source	Occurrences
(5S,6R)-5-hydroxy-6-methyl-3-[(2S,3S)-3-methyloxiran-2-yl]-5,6-dihydro-2H-pyran-2-one	REJECTED_LABEL	kg_microbe
aspyrone	REJECTED_LABEL	kg_microbe

Chemical properties

Cas rn: 156-38-7
Data source: PubChem API
Retrieval date: 2026-04-05T19:50:57.196667+00:00
Molecular formula: C8H8O3
Inchi: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
Smiles: O=C(O)Cc1ccc(O)cc1

Evidence (2)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

MANUAL_CURATION via cbclaw_kg_microbe_sweep

Corrected from CHEBI:156387 (aspyrone, a 2-pyranone natural product — wrong compound) to CHEBI:18101 (4-hydroxyphenylacetic acid). Caught by P2.5 kg-microbe cross-reference; CAS-RN 156-38-7 confirms CHEBI:18101.

Occurrence statistics

Total occurrences: 7
Distinct media: 7

Curation history

Timestamp	Curator	Action	New status	Changes
2026-03-09T06:54:18.022301+00:00	import_from_culturemech	IMPORTED	MAPPED	Initial import from CultureMech pipeline
2026-04-05T19:50:57.196726+00:00	fetch_cas_rn_from_pubchem	ADDED_CAS_RN	MAPPED	Added CAS-RN:156-38-7 from PubChem API via name lookup (4-Hydroxyphenyl acetic acid)
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	REMAPPED	MAPPED	Remapped CHEBI:156387 (aspyrone) → CHEBI:18101 (4-hydroxyphenylacetic acid). Original CHEBI:156387 is a 2-pyranone natural product unrelated to 4-hydroxyphenylacetic acid. CAS-RN 156-38-7 confirms correct CHEBI:18101.
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 2 synonyms from kg-microbe P4.4 enrichment: (5S,6R)-5-hydroxy-6-methyl-3-[(2S,3S)-3-methyloxiran-2-yl]-5,6-dihydro-2H-pyran-2-one, aspyrone
2026-05-01T07:35:31.928079+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:27.752965+00:00	auto_classify_ingredient_type	AUTO_BACKFILL_CHEBI_CHEMISTRY		molecular_formula=C8H8O3; inchi=InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H; smiles=O=C(O)Cc1ccc(O)cc1
2026-05-02T03:12:12.124990+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-06-09T04:56:30.247748+00:00	claude_in_session_curation	ANNOTATED		Added media role: CARBON_SOURCE (confidence: 0.60)
2026-07-20T00:00:00+00:00	migrate_media_roles_to_facets	ANNOTATED		Migrated legacy media_roles to role facets (#128): CARBON_SOURCE -> nutritional_roles.CARBON_SOURCE
2026-08-27T03:16:39.518277+00:00	refresh_occurrence_statistics	CORRECTED		occurrence_statistics 3/3 -> 7/7 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]
2026-09-20T00:00:00Z	retire_wrong_compound_synonyms LLM	CORRECTED		Marked 2 synonym(s) non-resolving: ['(5S,6R)-5-hydroxy-6-methyl-3-[(2S,3S)-3-methyloxiran-2-yl]-5,6-dihydro-2H-pyran-2-one', 'aspyrone']. ChEBI gives these names to CHEBI:156387, not to this record's CHEBI:18101 -- 4-hydroxyphenylacetic acid is not aspyrone. Kept as REJECTED_LABEL so a rebuild cannot restore them from kg-microbe's synonym list (#669).