Bacteriocin Isk 1

kgmicrobe.compound:bacteriocin_isk_1 chemically defined MAPPED kgmicrobe.compound PLACEHOLDER

Ontology mapping

Primary identifier
kgmicrobe.compound:bacteriocin_isk_1
Notes
2026-05-09 Falcon/OAK review: CHEBI:204272 is a Nukacin ISK-1 candidate, but local OAK/OLS did not provide a confirmable exact label/alias and Falcon-cited literature shows ambiguity between Pediococcus bacteriocin ISK-1 and Staphylococcus warneri nukacin ISK-1 usages. Retain kgmicrobe.compound:bacteriocin_isk_1 as the primary mapping and do not assert skos:exactMatch to CHEBI:204272 pending sequence/provenance confirmation.

Synonyms (4)

SynonymTypeSourceOccurrences
bacteriocin ISK-1 EXACT_SYNONYM unmapped_duplicate_review_2026_05_07
nukacin ISK-1 RELATED_SYNONYM FutureHouse Falcon deep research 2026-05-09
ISK-1 bacteriocin RELATED_SYNONYM FutureHouse Falcon deep research 2026-05-09
bacteriocin ISK-I RELATED_SYNONYM FutureHouse Falcon deep research 2026-05-09

Evidence (2)

DATABASE_MATCH via kg-microbe metatraits unmapped_compounds.tsv

Imported from kg-microbe's unmapped placeholder namespace. Ingested into MIM's pipeline; confidence=LOW; rationale=5 candidates; top OLS candidates: CHEBI:48081(bacteriocin), CHEBI:204272(Nukacin ISK-1), CHEBI:196278(Small bacteriocin). Pending curator promotion to a CHEBI/NCIT primary identifier.

LITERATURE via FutureHouse Falcon deep research (2026-05-09); DOI:10.5109/24265; DOI:10.1128/AAC.01623-08

Literature supports an ISK-1 lantibiotic/nukacin-related peptide, but producer and name usage spans Pediococcus bacteriocin ISK-1 and Staphylococcus warneri nukacin ISK-1. Retain the kgmicrobe placeholder and do not promote CHEBI:204272 without sequence or provenance confirmation.

Occurrence statistics

Total occurrences
0
Distinct media
0

Curation history

TimestampCuratorActionNew statusChanges
2026-04-26T04:54:19.839959+00:00 audit_curate_unmapped_kgm_antibiotics CREATED_FROM_KGM_PLACEHOLDER MAPPED Created MIM record from kg-microbe placeholder kgmicrobe.compound:bacteriocin_isk_1; OLS search across CHEBI+NCIT returned LOW-confidence (5 candidates). Identifier kept as kgmicrobe.compound: until upstream curation finds a CHEBI/NCIT primary.
2026-05-01T07:35:32.324422+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (kgmicrobe.compound placeholder (defined))
2026-05-02T03:12:12.684203+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (kgmicrobe.compound placeholder (defined))
2026-05-07T00:00:00+00:00 unmapped_duplicate_review_2026_05_07 MERGED_FROM_UNMAPPED_DUPLICATE MAPPED Absorbed duplicate unmapped record Bacteriocin_ISK-1.yaml (UNMAPPED_0592); source label matches kgmicrobe.compound:bacteriocin_isk_1 placeholder identity. CHEBI:204272 resolves as Nukacin ISK-1 but was not promoted because local evidence does not prove identity to the broader source label.
2026-05-09T20:44:29+00:00 mediaingredientmech-agentic-curation LLM ANNOTATED MAPPED Reviewed Falcon report and OAK/OLS evidence for CHEBI:204272. Literature supports ISK-1 lantibiotic/nukacin-related usage but shows producer and name-scope ambiguity, so CHEBI:204272 was not promoted to an exact identity mapping; related synonyms and caution note added.