Berberine — MIM

Ontology mapping

Primary identifier: CHEBI:31271
Ontology label: Berberine chloride (TN)

Synonyms (6)

Synonym	Type	Source
9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium	EXACT_SYNONYM	chebi_synonym_review
5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium	RAW_TEXT	sssom_other_backfill
7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-[methylenebis(oxy)]berbinium	RAW_TEXT	sssom_other_backfill
9,10-dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetradehydroberbinium	RAW_TEXT	sssom_other_backfill
Berberin	RAW_TEXT	sssom_other_backfill
Umbellatine	RAW_TEXT	sssom_other_backfill

Chemical properties

Cas rn: 633-65-8
Data source: CultureBotHT compounds_to_cas.csv
Retrieval date: 2026-04-29T06:04:17.380972+00:00
Molecular formula: C20H18NO4
Inchi: InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
Smiles: COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2

Evidence (2)

DATABASE_MATCH via CultureBotHT

Imported from CultureBotHT.

DATABASE_MATCH via MIM curation (#320)

identifier/ontology_id CHEBI:16118 ('berberine') -> CHEBI:31271 ('Berberine chloride (TN)'). The record's own cas_rn 633-65-8 is registered by ChEBI against CHEBI:31271, which is the chloride salt of the term the record previously carried. Curation decision on #320: where the CAS names a more specific FORM than the label, the CAS governs — the recipe is taken to mean the substance actually weighed out. These surfaced as 'unrelated' in the ancestry triage only because ChEBI does not model salt-of / hydrate-of / racemate-of as subsumption, the same gap #342 recorded for hydrates.

Occurrence statistics

Total occurrences: 0
Distinct media: 0

Curation history

Timestamp	Curator	Action	New status	Changes
2026-04-29T06:04:17.380972+00:00	audit_integrate_culturebotht	CREATED_FROM_CULTUREBOTHT	MAPPED	Created from CultureBotHT compounds_to_cas.csv (CAS=633-65-8); Imported from CultureBotHT.
2026-05-01T07:35:32.374684+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:28.183083+00:00	auto_classify_ingredient_type	AUTO_BACKFILL_CHEBI_CHEMISTRY		molecular_formula=C20H18NO4; inchi=InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18; smiles=COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2
2026-05-02T03:12:12.767340+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-08-13T00:00:00+00:00	reground_cas_specific_form	REGROUNDED_TO_CAS_SPECIFIC_FORM		identifier/ontology_id CHEBI:16118 -> CHEBI:31271 'Berberine chloride (TN)' (#320); the record's CAS 633-65-8 denotes the chloride salt. mapping_quality -> SYNONYM_MATCH.
2026-09-02T17:40:44.716277+00:00	claude_sssom_surface_form_backfill	ADDED_SYNONYMS		Recovered 1 surface form(s) that the published SSSOM `other` carried but no curated record did, so a rebuild would have dropped them from KGX: '5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium'. Tokens already present on the kg-microbe ontology node were left out as redundant (#520).
2026-09-02T22:41:49.137449+00:00	claude_sssom_surface_form_backfill	ADDED_SYNONYMS		Recovered 4 surface form(s) that the published SSSOM `other` carried but no curated record did, so a rebuild would have dropped them from KGX: '7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-[methylenebis(oxy)]berbinium'; '9,10-dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetradehydroberbinium'; 'Berberin'; 'Umbellatine'. Tokens already present on the kg-microbe ontology node were left out as redundant (#520).