Biotin

CHEBI:15956 chemically defined MAPPED CHEBI EXACT_MATCH

Ontology mapping

Primary identifier
CHEBI:15956
Ontology label
biotin
kg-microbe node
CHEBI:15956

Nutritional roles

Synonyms (23)

SynonymTypeSourceOccurrences
(alternative) RAW_TEXT CultureMech
Cross-references: KEGG:btn RAW_TEXT CultureMech
Role: Vitamin; Properties: Defined component, Organic compound, Simple component RAW_TEXT CultureMech
Role: Vitamin; Properties: Defined component, Simple component, Organic compound RAW_TEXT CultureMech
Role: Vitamin; Properties: Organic compound, Defined component, Simple component RAW_TEXT CultureMech
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid EXACT_SYNONYM kg_microbe
(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid EXACT_SYNONYM kg_microbe
5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid EXACT_SYNONYM kg_microbe
5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid EXACT_SYNONYM kg_microbe
Biotine EXACT_SYNONYM kg_microbe
Coenzyme R EXACT_SYNONYM kg_microbe
D(+)-Biotin EXACT_SYNONYM kg_microbe
D-(+)-biotin EXACT_SYNONYM kg_microbe
D-Biotin EXACT_SYNONYM kg_microbe
Vitamin H EXACT_SYNONYM kg_microbe
biotina EXACT_SYNONYM kg_microbe
biotinum EXACT_SYNONYM kg_microbe
cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid EXACT_SYNONYM kg_microbe
cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid EXACT_SYNONYM kg_microbe
cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid EXACT_SYNONYM kg_microbe
vitamin B7 EXACT_SYNONYM kg_microbe
Biotin (Vitamin B7) EXACT_SYNONYM unmapped_ols_exact_audit
Biotin (1 μg/μL) RAW_TEXT culturemech:output/ingredient_occurrences.tsv

Chemical properties

Cas rn
58-85-5
Data source
PubChem API
Retrieval date
2026-04-05T19:51:13.549860+00:00
Molecular formula
C10H16N2O3S
Inchi
InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
Smiles
[H][C@]12CS[C@@H](CCCCC(=O)O)[C@@]1([H])NC(=O)N2

Evidence (2)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

LITERATURE SUPPORTvia PubMed search ('Biotin') PMID:39201737
Several reports have demonstrated that pharmacological concentrations of biotin have therapeutic effects on MetS.

Auto-proposed; curator should rephrase or remove.

Occurrence statistics

Total occurrences
2,829
Distinct media
2,792

Curation history

TimestampCuratorActionNew statusChanges
2026-03-09T06:54:18.022301+00:00 import_from_culturemech IMPORTED MAPPED Initial import from CultureMech pipeline
2026-04-05T19:51:13.549909+00:00 fetch_cas_rn_from_pubchem ADDED_CAS_RN MAPPED Added CAS-RN:58-85-5 from PubChem API via name lookup (Biotin)
2026-04-05T21:48:44.764023+00:00 fetch_cas_rn_from_culturebot_csv ADDED_CAS_RN MAPPED Added CAS-RN:58-85-5 from CultureBotHT compounds_to_cas.csv (matched: biotin)
2026-04-05T21:48:44.941054+00:00 fetch_cas_rn_from_culturebot_csv ADDED_CAS_RN MAPPED Added CAS-RN:58-85-5 from CultureBotHT compounds_to_cas.csv (matched: D-Biotin)
2026-04-05T21:48:44.943050+00:00 fetch_cas_rn_from_culturebot_csv ADDED_CAS_RN MAPPED Added CAS-RN:58-85-5 from CultureBotHT compounds_to_cas.csv (matched: d-Biotin)
2026-04-05T21:48:44.945130+00:00 fetch_cas_rn_from_culturebot_csv ADDED_CAS_RN MAPPED Added CAS-RN:58-85-5 from CultureBotHT compounds_to_cas.csv (matched: D-biotin)
2026-04-05T21:48:44.976000+00:00 fetch_cas_rn_from_culturebot_csv ADDED_CAS_RN MAPPED Added CAS-RN:58-85-5 from CultureBotHT compounds_to_cas.csv (matched: D(+)-Biotin)
2026-04-09T00:32:50.689620+00:00 enrich_mim_cas_rn_batch CAS_RN_ADDED MAPPED Added CAS-RN 58-85-5 from PubChem (via CHEBI:15956)
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM ADDED_SYNONYMS MAPPED Added 16 synonyms from kg-microbe P4.4 enrichment: (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid, Biotine, ... (11 more)
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM ADDED_SYNONYMS MAPPED Added 15 synonyms from kg-microbe P4.4 enrichment: (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid, Biotine, ... (10 more)
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM ADDED_SYNONYMS MAPPED Added 15 synonyms from kg-microbe P4.4 enrichment: (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid, Coenzyme R, ... (10 more)
2026-04-19T07:39:23.955331+00:00 audit_mim_merge MERGED_FROM_DUPLICATES MAPPED Absorbed 7 duplicate MIM record(s) into this one: D-_-biotin.yaml, Biotine.yaml, D_-biotin.yaml, D-biotin.yaml, Biotin_2.yaml, D-biotin_2.yaml, D-biotin_3.yaml. Synonyms, curation_history, and occurrence counts were unioned/summed; winner selected by highest occurrence count with preferred_term readability tie-break.
2026-05-01T07:35:32.425960+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:28.237351+00:00 auto_classify_ingredient_type AUTO_BACKFILL_CHEBI_CHEMISTRY molecular_formula=C10H16N2O3S; inchi=InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7; smiles=[H][C@]12CS[C@@H](CCCCC(=O)O)[C@@]1([H])NC(=O)N2
2026-05-01T08:09:47.766513+00:00 auto_classify_ingredient_type APPLY_EVIDENCE_PROPOSAL added pmid=39201737 from propose-evidence batch
2026-05-02T03:12:12.844145+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-05-06T00:00:00+00:00 unmapped_ols_exact_audit MERGED_FROM_UNMAPPED_DUPLICATE MAPPED Added exact synonym "Biotin (Vitamin B7)" and retired duplicate unmapped record Biotin_(Vitamin_B7).yaml after OLS exact match to CHEBI:15956.
2026-05-29T23:35:36.110268+00:00 extract_roles_from_synonyms ANNOTATED Added media role: VITAMIN_SOURCE (confidence: 1.00)
2026-06-09T05:23:46.731014+00:00 correct_stale_ontology_labels.py CORRECTED ontology_label 'Biotin' -> 'biotin': synced to canonical CHEBI label (preferred_term 'Biotin' unchanged).
2026-07-20T00:00:00+00:00 migrate_media_roles_to_facets ANNOTATED Migrated legacy media_roles to role facets (#128): VITAMIN_SOURCE -> nutritional_roles.VITAMIN_SOURCE
2026-08-27T03:16:39.518434+00:00 refresh_occurrence_statistics CORRECTED occurrence_statistics 158/2421 -> 2792/2829 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]
2026-08-31T23:56:54.854807+00:00 claude_culturemech_alias_backfill ADDED_SYNONYMS Added 1 CultureMech recipe surface form(s) that folded onto this record's published label but were absent from MIM's label index, so CultureMech could not resolve them: 'Biotin (1 μg/μL)' (x1 CultureMech mentions). Source: culturemech:output/ingredient_occurrences.tsv.