Folic acid

CHEBI:27470 chemically defined MAPPED CHEBI EXACT_MATCH

Ontology mapping

Primary identifier
CHEBI:27470
Ontology label
folic acid
kg-microbe node
CHEBI:27470

Nutritional roles

Synonyms (24)

SynonymTypeSourceOccurrences
Role: Vitamin; Properties: Defined component, Simple component, Organic compound RAW_TEXT CultureMech
Role: Vitamin; Properties: Organic compound, Defined component, Simple component RAW_TEXT CultureMech
Role: Vitamin; Properties: Organic compound, Simple component, Defined component RAW_TEXT CultureMech
Folate EXACT manual
(2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid EXACT_SYNONYM kg_microbe
Acfol EXACT_SYNONYM kg_microbe
Folicet EXACT_SYNONYM kg_microbe
Folinic acid (citrovorum) EXACT_SYNONYM kg_microbe
Folsaeure EXACT_SYNONYM kg_microbe
N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid EXACT_SYNONYM kg_microbe
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid EXACT_SYNONYM kg_microbe
N-pteroyl-L-glutamic acid EXACT_SYNONYM kg_microbe
PGA EXACT_SYNONYM kg_microbe
PteGlu EXACT_SYNONYM kg_microbe
acide folique EXACT_SYNONYM kg_microbe
acido folico EXACT_SYNONYM kg_microbe
acidum folicum EXACT_SYNONYM kg_microbe
pteroyl-L-glutamic acid EXACT_SYNONYM kg_microbe
pteroyl-L-monoglutamic acid EXACT_SYNONYM kg_microbe
pteroylglutamic acid EXACT_SYNONYM kg_microbe
pteroylmonoglutamic acid EXACT_SYNONYM kg_microbe
vitamin B11 EXACT_SYNONYM kg_microbe
vitamin B9 EXACT_SYNONYM kg_microbe
Folic acid (5 μg/μL) RAW_TEXT culturemech:output/ingredient_occurrences.tsv

Chemical properties

Cas rn
59-30-3
Data source
PubChem API
Retrieval date
2026-04-05T19:52:10.067126+00:00
Molecular formula
C19H19N7O6
Inchi
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
Smiles
Nc1nc(=O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1

Evidence (2)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

LITERATURE SUPPORTvia PubMed search ('Folic acid') PMID:20415580
The only recommendation for pregnancy currently exists for iron and folic acid use.

Auto-proposed; curator should rephrase or remove.

Occurrence statistics

Total occurrences
2,111
Distinct media
2,108

Curation history

TimestampCuratorActionNew statusChanges
2026-03-09T06:54:18.022301+00:00 import_from_culturemech IMPORTED MAPPED Initial import from CultureMech pipeline
2026-04-05T19:52:10.067165+00:00 fetch_cas_rn_from_pubchem ADDED_CAS_RN MAPPED Added CAS-RN:59-30-3 from PubChem API via name lookup (Folic acid)
2026-04-05T21:48:45.106229+00:00 fetch_cas_rn_from_culturebot_csv ADDED_CAS_RN MAPPED Added CAS-RN:59-30-3 from CultureBotHT compounds_to_cas.csv (matched: Folic Acid)
2026-04-05T21:48:45.108282+00:00 fetch_cas_rn_from_culturebot_csv ADDED_CAS_RN MAPPED Added CAS-RN:59-30-3 from CultureBotHT compounds_to_cas.csv (matched: folic acid)
2026-04-17T12:00:00+00:00 synonym_expansion_cbclaw LLM ADDED_SYNONYMS MAPPED Added 1 synonym for unmapped CultureMech surface form
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM ADDED_SYNONYMS MAPPED Added 19 synonyms from kg-microbe P4.4 enrichment: (2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid, Acfol, Folicet, Folinic acid (citrovorum), Folsaeure, ... (14 more)
2026-04-19T07:39:23.955331+00:00 audit_mim_merge MERGED_FROM_DUPLICATES MAPPED Absorbed 2 duplicate MIM record(s) into this one: Folic_Acid_2.yaml, Folic_Acid_3.yaml. Synonyms, curation_history, and occurrence counts were unioned/summed; winner selected by highest occurrence count with preferred_term readability tie-break.
2026-05-01T07:35:33.664745+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:29.638042+00:00 auto_classify_ingredient_type AUTO_BACKFILL_CHEBI_CHEMISTRY molecular_formula=C19H19N7O6; inchi=InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23; smiles=Nc1nc(=O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O
2026-05-01T08:09:47.856867+00:00 auto_classify_ingredient_type APPLY_EVIDENCE_PROPOSAL added pmid=20415580 from propose-evidence batch
2026-05-02T03:12:14.540097+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-05-29T23:35:36.111180+00:00 extract_roles_from_synonyms ANNOTATED Added media role: VITAMIN_SOURCE (confidence: 1.00)
2026-06-09T05:23:46.765867+00:00 correct_stale_ontology_labels.py CORRECTED ontology_label 'Folic acid' -> 'folic acid': synced to canonical CHEBI label (preferred_term 'Folic acid' unchanged).
2026-07-20T00:00:00+00:00 migrate_media_roles_to_facets ANNOTATED Migrated legacy media_roles to role facets (#128): VITAMIN_SOURCE -> nutritional_roles.VITAMIN_SOURCE
2026-08-27T03:16:39.518900+00:00 refresh_occurrence_statistics CORRECTED occurrence_statistics 54/1727 -> 2108/2111 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]
2026-08-31T23:56:54.854807+00:00 claude_culturemech_alias_backfill ADDED_SYNONYMS Added 1 CultureMech recipe surface form(s) that folded onto this record's published label but were absent from MIM's label index, so CultureMech could not resolve them: 'Folic acid (5 μg/μL)' (x1 CultureMech mentions). Source: culturemech:output/ingredient_occurrences.tsv.