Glutathione

CHEBI:16856 chemically defined MAPPED CHEBI EXACT_MATCH

Ontology mapping

Primary identifier
CHEBI:16856
Ontology label
glutathione
kg-microbe node
CHEBI:16856

Nutritional roles

Synonyms (12)

SynonymTypeSourceOccurrences
Cross-references: KEGG:gthrd RAW_TEXT CultureMech
Role: Nitrogen source; Properties: Defined component, Organic compound, Simple component RAW_TEXT CultureMech
Role: Nitrogen source; Properties: Organic compound, Defined component, Simple component RAW_TEXT CultureMech
5-L-Glutamyl-L-cysteinylglycine EXACT_SYNONYM kg_microbe
GSH EXACT_SYNONYM kg_microbe
Glutathione-SH EXACT_SYNONYM kg_microbe
L-gamma-glutamyl-L-cysteinylglycine EXACT_SYNONYM kg_microbe
N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine EXACT_SYNONYM kg_microbe
Reduced glutathione EXACT_SYNONYM kg_microbe
gamma-L-Glutamyl-L-cysteinyl-glycine EXACT_SYNONYM kg_microbe
L-Glutathione RAW_TEXT merged_record
L-glutathione reduced EXACT_SYNONYM CultureMech label unresolvable via label_index (#260)

Chemical properties

Cas rn
70-18-8
Data source
PubChem API
Retrieval date
2026-04-05T19:52:16.007341+00:00
Molecular formula
C10H17N3O6S
Inchi
InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
Smiles
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O

Evidence (2)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

MANUAL_CURATION via MIM curation (#260)

Added 'L-glutathione reduced' as a EXACT_SYNONYM (#260): CHEBI:16856 'glutathione' IS the reduced form (GSH) — the record already lists `Reduced glutathione` and `GSH`, and the oxidised form is a separate record on CHEBI:17858. The `L-` and `reduced` qualifiers add nothing the term does not already fix. CultureMech uses this surface form and label_index did not contain it, so the lookup missed. No new record: CHEBI:16856 is this record's identifier, and in MIM the identifier IS the ontology CURIE, so a second record on it would be a duplicate primary key rather than added coverage.

Occurrence statistics

Total occurrences
32
Distinct media
32

Curation history

TimestampCuratorActionNew statusChanges
2026-03-09T06:54:18.022301+00:00 import_from_culturemech IMPORTED MAPPED Initial import from CultureMech pipeline
2026-04-05T19:52:16.007386+00:00 fetch_cas_rn_from_pubchem ADDED_CAS_RN MAPPED Added CAS-RN:70-18-8 from PubChem API via name lookup (Glutathione)
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM ADDED_SYNONYMS MAPPED Added 7 synonyms from kg-microbe P4.4 enrichment: 5-L-Glutamyl-L-cysteinylglycine, GSH, Glutathione-SH, L-gamma-glutamyl-L-cysteinylglycine, N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine, ... (2 more)
2026-05-01T07:35:33.808529+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:29.771226+00:00 auto_classify_ingredient_type AUTO_BACKFILL_CHEBI_CHEMISTRY molecular_formula=C10H17N3O6S; inchi=InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(; smiles=N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
2026-05-02T03:12:14.731019+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-05-29T23:35:36.111279+00:00 extract_roles_from_synonyms ANNOTATED Added media role: NITROGEN_SOURCE (confidence: 1.00)
2026-07-20T00:00:00+00:00 migrate_media_roles_to_facets ANNOTATED Migrated legacy media_roles to role facets (#128): NITROGEN_SOURCE -> nutritional_roles.NITROGEN_SOURCE
2026-08-05T06:55:18.095607+00:00 merge-same-substance-batch LLM MERGED_FROM_MAPPED_RECORD Absorbed CHEBI:16856 'L-Glutathione': 1 synonym(s), occurrences +0/0. Same substance under two names; MERGE_SAME_SUBSTANCE in duplicate_identifier_baseline.tsv (#226). Source: mediadive.ingredient:2085.
2026-08-15T00:00:00+00:00 add_culturemech_gap_labels ADDED_SYNONYM_FOR_CULTUREMECH_GAP Added 'L-glutathione reduced' as a EXACT_SYNONYM (#260): CHEBI:16856 'glutathione' IS the reduced form (GSH) — the record already lists `Reduced glutathione` and `GSH`, and the oxidised form is a separate record on CHEBI:17858. The `L-` and `reduced` qualifiers add nothing the term does not already fix. CultureMech uses this surface form and label_index did not contain it, so the lookup missed. No new record: CHEBI:16856 is this record's identifier, and in MIM the identifier IS the ontology CURIE, so a second record on it would be a duplicate primary key rather than added coverage.
2026-08-27T03:16:39.518940+00:00 refresh_occurrence_statistics CORRECTED occurrence_statistics 13/13 -> 32/32 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]