L-Cysteine HCl x H2O

Ontology mapping

Primary identifier: CHEBI:91248
Ontology label: L-cysteine hydrochloride hydrate

Nutritional roles

Role
AMINO_ACID_SOURCE
Confidence
0.8
Evidence
- Reference type
  COMPUTATIONAL_PREDICTION
  Reference text
  Inferred from curated media-role name pattern
  Curator note
  Provisional role from a curated name-pattern rule; review recommended.

Synonyms (27)

Synonym	Type	Source
Properties: Defined component, Organic compound, Simple component	RAW_TEXT	CultureMech
Properties: Simple component, Defined component, Organic compound	RAW_TEXT	CultureMech
L--Cysteine・HCl・H2O	HYDRATE_FORM	manual
L-Cysteine・HCl・H2O	HYDRATE_FORM	manual
L--cysteine・HCl・H2O	HYDRATE_FORM	manual
L--Cysteine HCl H2O	HYDRATE_FORM	manual
L-Cysteine HCl monohydrate	EXACT	manual
(2R)-2-Amino-3-sulfanyl-propanoic acid hydrochloride monohydrate	EXACT_SYNONYM	kg_microbe
Cystein-HCl x 2 H2O (5% (w/v))	HYDRATE_FORM	kg_microbe
L-Cysteine hydrochloride monohydrate	EXACT_SYNONYM	kg_microbe
L-Cysteine monohydrate monochloride	EXACT_SYNONYM	kg_microbe
L-cysteine HCl.H2O	HYDRATE_FORM	kg_microbe
L-cysteine hydrochloride hydrate	EXACT_SYNONYM	kg_microbe
L-Cysteine-HCl x H2O	HYDRATE_FORM	merged_from_duplicate_mim_record
Cysteine hydrochloride	EXACT_SYNONYM	merged_from_duplicate_mim_record
Cysteine-HCl x H2O	HYDRATE_FORM	merged_from_duplicate_mim_record
Properties: Defined component, Simple component, Organic compound	RAW_TEXT	CultureMech
Properties: Organic compound, Defined component, Simple component	RAW_TEXT	CultureMech
Properties: Organic compound, Simple component, Defined component	RAW_TEXT	CultureMech
Properties: Simple component, Organic compound, Defined component	RAW_TEXT	CultureMech
Cysteine-HCl·H2O	HYDRATE_FORM	kg_microbe
Cysteine-HCl∙H2O	HYDRATE_FORM	kg_microbe
Cysteine-HCl⋅H2O	HYDRATE_FORM	kg_microbe
L-Cysteine-HCl·H2O	HYDRATE_FORM	kg_microbe
(1R)-1-carboxy-2-sulfanylethan-1-aminium chloride--water (1/1)	EXACT_SYNONYM	kg_microbe
L-cysteine hydrochloride--water (1/1)	EXACT_SYNONYM	kg_microbe
Cystein-HCl	RAW_TEXT	sssom_other_backfill

Chemical properties

Cas rn: 7048-04-6
Data source: PubChem (via CHEBI:91248)
Retrieval date: 2026-04-09T00:32:50.689620+00:00
Molecular formula: C3H7NO2S.H2O.HCl
Inchi: InChI=1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1
Smiles: Cl.N[C@@H](CS)C(=O)O.O

Evidence (1)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

Occurrence statistics

Total occurrences: 1,768
Distinct media: 1,767

Curation history

Timestamp	Curator	Action	New status	Changes
2026-03-09T06:54:18.022301+00:00	import_from_culturemech	IMPORTED	MAPPED	Initial import from CultureMech pipeline
2026-04-05T19:51:40.943385+00:00	fetch_cas_rn_from_pubchem	ADDED_CAS_RN	MAPPED	Added CAS-RN:200-157-7 from PubChem API via name lookup (Cysteine hydrochloride)
2026-04-05T21:48:44.932471+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:52-90-4 from CultureBotHT compounds_to_cas.csv (matched: Cysteine-HCl x H2O)
2026-04-05T21:48:45.245748+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:52-90-4 from CultureBotHT compounds_to_cas.csv (matched: L-Cysteine-HCl x H2O)
2026-04-05T21:48:45.247978+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:52-90-4 from CultureBotHT compounds_to_cas.csv (matched: L-cysteine-HCL x H2O)
2026-04-09T00:32:50.689620+00:00	enrich_mim_cas_rn_batch	CAS_RN_ADDED	MAPPED	Added CAS-RN 7048-04-6 from PubChem (via CHEBI:91248)
2026-04-17T12:00:00+00:00	synonym_expansion_cbclaw LLM	ADDED_SYNONYMS	MAPPED	Added 5 synonyms (unicode and ASCII variants) for unmapped CultureMech surface forms
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 6 synonyms from kg-microbe P4.4 enrichment: (2R)-2-Amino-3-sulfanyl-propanoic acid hydrochloride monohydrate, Cystein-HCl x 2 H2O (5% (w/v)), L-Cysteine hydrochloride monohydrate, L-Cysteine monohydrate monochloride, L-cysteine HCl.H2O, ... (1 more)
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	REMAPPED	MAPPED	Remapped CHEBI:17561 (free L-cysteine) → CHEBI:91248 (L-cysteine hydrochloride hydrate). Previous CAS-RN 52-90-4 also incorrect (belongs to free L-cysteine); corrected to 7048-04-6 (L-cysteine HCl monohydrate).
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 3 synonyms from kg-microbe P4.4 enrichment: Cysteine-HCl·H2O, Cysteine-HCl⋅H2O, L-Cysteine-HCl·H2O
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 2 synonyms from kg-microbe P4.4 enrichment: (1R)-1-carboxy-2-sulfanylethan-1-aminium chloride--water (1/1), L-cysteine hydrochloride--water (1/1)
2026-04-19T07:39:23.955331+00:00	audit_mim_merge	MERGED_FROM_DUPLICATES	MAPPED	Absorbed 4 duplicate MIM record(s) into this one: L-cysteine-hcl_X_H2o.yaml, Cysteine_Hydrochloride.yaml, Cysteine-hcl_X_H2o.yaml, L-cysteine-hcl_X_H2o_2.yaml. Synonyms, curation_history, and occurrence counts were unioned/summed; winner selected by highest occurrence count with preferred_term readability tie-break.
2026-05-01T07:35:34.331010+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:30.336963+00:00	auto_classify_ingredient_type	AUTO_BACKFILL_CHEBI_CHEMISTRY		molecular_formula=C3H7NO2S.H2O.HCl; inchi=InChI=1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1; smiles=Cl.N[C@@H](CS)C(=O)O.O
2026-05-02T03:12:15.487863+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-06-03T02:06:01.743410+00:00	infer_roles_from_name_lists	ANNOTATED		Added media role: AMINO_ACID_SOURCE (confidence: 0.80)
2026-06-09T05:23:46.784615+00:00	correct_stale_ontology_labels.py	CORRECTED		ontology_label 'L-Cysteine HCl x H2O' -> 'L-cysteine hydrochloride hydrate': synced to canonical CHEBI label (preferred_term 'L-Cysteine HCl x H2O' unchanged).
2026-07-20T00:00:00+00:00	migrate_media_roles_to_facets	ANNOTATED		Migrated legacy media_roles to role facets (#128): AMINO_ACID_SOURCE -> nutritional_roles.AMINO_ACID_SOURCE
2026-08-20T00:00:00+00:00	merge_identifier_collisions	MERGED_FROM		Absorbed 'L-Cysteine hydrochloride monohydrate' (#414). Both records held CHEBI:91248 while both were live, which MIM's own rule forbids — for a mapped record the identifier IS the ontology CURIE, so two live records on it assert that two ingredients are one thing. They are one thing: abbreviation versus full name; identical CAS 7048-04-6 and formula C3H7NO2S.H2O.HCl, both explicitly the monohydrate. 'L-Cysteine HCl x H2O' wins as the label media actually use (1027 occurrences against 13); the other survives as a RAW_TEXT synonym, so label_index still answers for it.
2026-08-27T03:16:39.519131+00:00	refresh_occurrence_statistics	CORRECTED		occurrence_statistics 131/1040 -> 1767/1768 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]
2026-09-02T17:40:44.716277+00:00	claude_sssom_surface_form_backfill	ADDED_SYNONYMS		Recovered 1 surface form(s) that the published SSSOM `other` carried but no curated record did, so a rebuild would have dropped them from KGX: 'Cystein-HCl'. Tokens already present on the kg-microbe ontology node were left out as redundant (#520).
2026-09-10T06:14:55Z	mediaingredientmech-agentic-curation LLM	CORRECTED		Added bullet-operator hydrate synonym Cysteine-HCl∙H2O moved from free L-cysteine; this spelling names L-cysteine hydrochloride hydrate CHEBI:91248 (#521).