Meropenem — MIM

Ontology mapping

Primary identifier: CHEBI:6770
Ontology label: meropenem trihydrate

Physicochemical roles

Role
SELECTIVE_AGENT
Confidence
0.8
Evidence
- Reference type
  COMPUTATIONAL_PREDICTION
  Reference text
  Inferred from curated media-role name pattern
  Curator note
  Provisional role from a curated name-pattern rule; review recommended.

Synonyms (8)

Synonym	Type	Source
(6S)-2-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-1beta-methyl-2,3-didehydro-1-carbapenam-3-carboxylic acid	EXACT_SYNONYM	chebi_synonym_review
(1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-YLTHIO]-6-[(R)-1-HYDROXYETHYL]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLIC ACID	RAW_TEXT	sssom_other_backfill
(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid	RAW_TEXT	sssom_other_backfill
Antibiotic SM 7338	RAW_TEXT	sssom_other_backfill
MEM	RAW_TEXT	sssom_other_backfill
MEPM	RAW_TEXT	sssom_other_backfill
meropenem anhydrous	RAW_TEXT	sssom_other_backfill
meropenemum	RAW_TEXT	sssom_other_backfill

Chemical properties

Cas rn: 119478-56-7
Data source: CultureBotHT compounds_to_cas.csv
Retrieval date: 2026-04-29T06:04:17.380972+00:00
Molecular formula: C17H25N3O5S
Inchi: InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1
Smiles: [H][C@]12[C@@H](C)C(S[C@@H]3CN[C@H](C(=O)N(C)C)C3)=C(C(=O)O)N1C(=O)[C@]2([H])[C@@H](C)O

Evidence (2)

DATABASE_MATCH via CultureBotHT

Imported from CultureBotHT.

DATABASE_MATCH via MIM curation (#320)

identifier/ontology_id CHEBI:43968 ('meropenem') -> CHEBI:6770 ('meropenem trihydrate'). The record's own cas_rn 119478-56-7 is registered by ChEBI against CHEBI:6770, which is the trihydrate of the term the record previously carried. Curation decision on #320: where the CAS names a more specific FORM than the label, the CAS governs — the recipe is taken to mean the substance actually weighed out. These surfaced as 'unrelated' in the ancestry triage only because ChEBI does not model salt-of / hydrate-of / racemate-of as subsumption, the same gap #342 recorded for hydrates.

Occurrence statistics

Total occurrences: 0
Distinct media: 0

Curation history

Timestamp	Curator	Action	New status	Changes
2026-04-29T06:04:17.380972+00:00	audit_integrate_culturebotht	CREATED_FROM_CULTUREBOTHT	MAPPED	Created from CultureBotHT compounds_to_cas.csv (CAS=119478-56-7); Imported from CultureBotHT.
2026-05-01T07:35:34.666531+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:30.702479+00:00	auto_classify_ingredient_type	AUTO_BACKFILL_CHEBI_CHEMISTRY		molecular_formula=C17H25N3O5S; inchi=InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12; smiles=[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@H](C(=O)N(C)C)C3)
2026-05-02T03:12:16.295257+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-06-02T07:05:13.391043+00:00	infer_roles_from_name_lists	ANNOTATED		Added media role: SELECTIVE_AGENT (confidence: 0.80)
2026-07-20T00:00:00+00:00	migrate_media_roles_to_facets	ANNOTATED		Migrated legacy media_roles to role facets (#128): SELECTIVE_AGENT -> physicochemical_roles.SELECTIVE_AGENT
2026-08-13T00:00:00+00:00	reground_cas_specific_form	REGROUNDED_TO_CAS_SPECIFIC_FORM		identifier/ontology_id CHEBI:43968 -> CHEBI:6770 'meropenem trihydrate' (#320); the record's CAS 119478-56-7 denotes the trihydrate. mapping_quality -> SYNONYM_MATCH.
2026-09-02T17:40:44.716277+00:00	claude_sssom_surface_form_backfill	ADDED_SYNONYMS		Recovered 1 surface form(s) that the published SSSOM `other` carried but no curated record did, so a rebuild would have dropped them from KGX: '(1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-YLTHIO]-6-[(R)-1-HYDROXYETHYL]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLIC ACID'. Tokens already present on the kg-microbe ontology node were left out as redundant (#520).
2026-09-02T22:41:49.137449+00:00	claude_sssom_surface_form_backfill	ADDED_SYNONYMS		Recovered 6 surface form(s) that the published SSSOM `other` carried but no curated record did, so a rebuild would have dropped them from KGX: '(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid'; 'Antibiotic SM 7338'; 'MEM'; 'MEPM'; 'meropenem anhydrous'; 'meropenemum'. Tokens already present on the kg-microbe ontology node were left out as redundant (#520).