Nicotinic acid

Ontology mapping

Primary identifier: CHEBI:15940
Ontology label: nicotinic acid
kg-microbe node: CHEBI:15940

Nutritional roles

Role
VITAMIN_SOURCE
Confidence
1.0
Evidence
- Reference text
  CultureMech database (1998 occurrences as 'Vitamin')
  Reference type
  DATABASE_ENTRY
  Url
  https://github.com/CultureBotAI/CultureMech
  Excerpt
  Role: Vitamin; Properties: Defined component, Organic compound, Simple component
  Curator note
  Widespread use in media formulations (1998 occurrences). High confidence based on 'Defined component' property.

Synonyms (24)

Synonym	Type	Source
Role: Vitamin; Properties: Defined component, Organic compound, Simple component	RAW_TEXT	CultureMech
Role: Vitamin; Properties: Defined component, Simple component, Organic compound	RAW_TEXT	CultureMech
Role: Vitamin; Properties: Organic compound, Defined component, Simple component	RAW_TEXT	CultureMech
Nicotinate	EXACT	manual
Niacin	EXACT	manual
3-Pyridylcarboxylic acid	EXACT_SYNONYM	kg_microbe
3-carboxylpyridine	EXACT_SYNONYM	kg_microbe
3-carboxypyridine	EXACT_SYNONYM	kg_microbe
3-pyridinecarboxylic acid	EXACT_SYNONYM	kg_microbe
Niacor	EXACT_SYNONYM	kg_microbe
Niaspan	EXACT_SYNONYM	kg_microbe
Nicotinic acid (PP)	EXACT_SYNONYM	kg_microbe
Nicotinsaure	EXACT_SYNONYM	kg_microbe
Nikotinsaeure	EXACT_SYNONYM	kg_microbe
P.P. factor	EXACT_SYNONYM	kg_microbe
PP factor	EXACT_SYNONYM	kg_microbe
acide nicotinique	EXACT_SYNONYM	kg_microbe
acido nicotinico	EXACT_SYNONYM	kg_microbe
acidum nicotinicum	EXACT_SYNONYM	kg_microbe
anti-pellagra vitamin	EXACT_SYNONYM	kg_microbe
beta-pyridinecarboxylic acid	EXACT_SYNONYM	kg_microbe
m-pyridinecarboxylic acid	EXACT_SYNONYM	kg_microbe
pellagra preventive factor	EXACT_SYNONYM	kg_microbe
pyridine-3-carboxylic acid	EXACT_SYNONYM	kg_microbe

Chemical properties

Cas rn: 59-67-6
Data source: CultureBotHT compounds_to_cas.csv
Retrieval date: 2026-04-05T21:48:45.598514+00:00
Molecular formula: C6H5NO2
Inchi: InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
Smiles: O=C(O)c1cccnc1

Evidence (2)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

LITERATURE SUPPORTvia PubMed search ('Nicotinic acid') PMID:41213409

Hepatocellular carcinoma (HCC), an incurable malignancy with limited therapeutic options, exhibits mitochondrial dysfunction upon co-treatment with S-adenosylmethionine (SAM) and nicotinic acid (NA); however, the underlying mechanisms were undefined.

Auto-proposed; curator should rephrase or remove.

Occurrence statistics

Total occurrences: 2,222
Distinct media: 2,221

Curation history

Timestamp	Curator	Action	New status	Changes
2026-03-09T06:54:18.022301+00:00	import_from_culturemech	IMPORTED	MAPPED	Initial import from CultureMech pipeline
2026-04-05T19:53:32.968554+00:00	fetch_cas_rn_from_pubchem	ADDED_CAS_RN	MAPPED	Added CAS-RN:59-67-6 from PubChem API via name lookup (Niacin)
2026-04-05T21:48:45.583138+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:59-67-6 from CultureBotHT compounds_to_cas.csv (matched: niacin)
2026-04-05T21:48:45.598517+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:59-67-6 from CultureBotHT compounds_to_cas.csv (matched: Nicotinic acid)
2026-04-05T21:48:45.600467+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:59-67-6 from CultureBotHT compounds_to_cas.csv (matched: Nicotinic Acid)
2026-04-17T12:00:00+00:00	synonym_expansion_cbclaw LLM	ADDED_SYNONYMS	MAPPED	Added 2 synonyms for unmapped CultureMech surface forms
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 19 synonyms from kg-microbe P4.4 enrichment: 3-Pyridylcarboxylic acid, 3-carboxylpyridine, 3-carboxypyridine, 3-pyridinecarboxylic acid, Niacor, ... (14 more)
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 16 synonyms from kg-microbe P4.4 enrichment: 3-Pyridylcarboxylic acid, 3-carboxylpyridine, 3-carboxypyridine, 3-pyridinecarboxylic acid, Niacor, ... (11 more)
2026-04-19T07:39:23.955331+00:00	audit_mim_merge	MERGED_FROM_DUPLICATES	MAPPED	Absorbed 3 duplicate MIM record(s) into this one: Niacin.yaml, Nicotinic_Acid_2.yaml, Niacin_2.yaml. Synonyms, curation_history, and occurrence counts were unioned/summed; winner selected by highest occurrence count with preferred_term readability tie-break.
2026-05-01T07:35:35.561031+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:31.660554+00:00	auto_classify_ingredient_type	AUTO_BACKFILL_CHEBI_CHEMISTRY		molecular_formula=C6H5NO2; inchi=InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9; smiles=O=C(O)c1cccnc1
2026-05-01T08:09:48.075494+00:00	auto_classify_ingredient_type	APPLY_EVIDENCE_PROPOSAL		added pmid=41213409 from propose-evidence batch
2026-05-02T03:12:17.443349+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-05-29T23:35:36.112478+00:00	extract_roles_from_synonyms	ANNOTATED		Added media role: VITAMIN_SOURCE (confidence: 1.00)
2026-06-09T05:23:46.813111+00:00	correct_stale_ontology_labels.py	CORRECTED		ontology_label 'Nicotinic acid' -> 'nicotinic acid': synced to canonical CHEBI label (preferred_term 'Nicotinic acid' unchanged).
2026-07-20T00:00:00+00:00	migrate_media_roles_to_facets	ANNOTATED		Migrated legacy media_roles to role facets (#128): VITAMIN_SOURCE -> nutritional_roles.VITAMIN_SOURCE
2026-08-27T03:16:39.519625+00:00	refresh_occurrence_statistics	CORRECTED		occurrence_statistics 71/1998 -> 2221/2222 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]