Nitrilotriacetic acid

Ontology mapping

Primary identifier: CHEBI:44557
Ontology label: nitrilotriacetic acid
kg-microbe node: CHEBI:44557

Physicochemical roles

Role
CHELATOR
Confidence
1.0
Evidence
- Reference text
  CultureMech database (1154 occurrences as 'Mineral source')
  Reference type
  DATABASE_ENTRY
  Url
  https://github.com/CultureBotAI/CultureMech
  Excerpt
  Role: Mineral source; Properties: Organic compound, Defined component, Simple component
  Curator note
  Widespread use in media formulations (1154 occurrences). High confidence based on 'Defined component' property.

Synonyms (17)

Synonym	Type	Source
( disodium salt)	RAW_TEXT	CultureMech
( trisodium salt)	RAW_TEXT	CultureMech
Role: Mineral source; Properties: Organic compound, Defined component, Simple component	RAW_TEXT	CultureMech
Role: Mineral source; Properties: Organic compound, Simple component, Defined component	RAW_TEXT	CultureMech
Complexon I	EXACT_SYNONYM	kg_microbe
H3nta	EXACT_SYNONYM	kg_microbe
Komplexon I	EXACT_SYNONYM	kg_microbe
N(CH2-COOH)3	EXACT_SYNONYM	kg_microbe
N,N-bis(carboxymethyl)glycine	EXACT_SYNONYM	kg_microbe
Nitrilotriacetic acid (NTA)	EXACT_SYNONYM	kg_microbe
Nitrilotriessigsaeure	EXACT_SYNONYM	kg_microbe
Triglycollamic acid	EXACT_SYNONYM	kg_microbe
Trilon A	EXACT_SYNONYM	kg_microbe
alpha,alpha',alpha''-trimethylaminetricarboxylic acid	EXACT_SYNONYM	kg_microbe
nitrilo-2,2',2''-triacetic acid	EXACT_SYNONYM	kg_microbe
tri(carboxymethyl)amine	EXACT_SYNONYM	kg_microbe
triglycine	EXACT_SYNONYM	kg_microbe

Chemical properties

Cas rn: 139-13-9
Data source: PubChem API
Retrieval date: 2026-04-05T19:53:35.196893+00:00
Molecular formula: C6H9NO6
Inchi: InChI=1S/C6H9NO6/c8-4(9)1-7(2-5(10)11)3-6(12)13/h1-3H2,(H,8,9)(H,10,11)(H,12,13)
Smiles: O=C(O)CN(CC(=O)O)CC(=O)O

Evidence (2)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

LITERATURE SUPPORTvia PubMed search ('Nitrilotriacetic acid') PMID:34939907

Here we explore the potential of nitrilotriacetic acid-ditetra-decylamine (NTA3-DTDA)-containing liposomes (NTA-liposomes) engrafted with His-tagged forms of 'self' peptide (pCD47) to prolong circulation time in blood after iv administration, and of iRGD peptide (piRGD) to enhance treatment efficacy of doxorubicin-containing liposomes (Caelyx).

Auto-proposed; curator should rephrase or remove.

Occurrence statistics

Total occurrences: 1,348
Distinct media: 1,348

Curation history

Timestamp	Curator	Action	New status	Changes
2026-03-09T06:54:18.022301+00:00	import_from_culturemech	IMPORTED	MAPPED	Initial import from CultureMech pipeline
2026-04-05T19:53:35.196927+00:00	fetch_cas_rn_from_pubchem	ADDED_CAS_RN	MAPPED	Added CAS-RN:139-13-9 from PubChem API via name lookup (Nitrilotriacetic acid)
2026-04-05T21:48:45.607332+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:139-13-9 from CultureBotHT compounds_to_cas.csv (matched: Nitrilotriacetic Acid)
2026-04-05T21:48:45.609229+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:139-13-9 from CultureBotHT compounds_to_cas.csv (matched: nitrilotriacetic acid)
2026-04-05T21:48:45.611307+00:00	fetch_cas_rn_from_culturebot_csv	ADDED_CAS_RN	MAPPED	Added CAS-RN:139-13-9 from CultureBotHT compounds_to_cas.csv (matched: Nitrilotriacetic acid (NTA))
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 13 synonyms from kg-microbe P4.4 enrichment: Complexon I, H3nta, Komplexon I, N(CH2-COOH)3, N,N-bis(carboxymethyl)glycine, ... (8 more)
2026-04-18T00:00:00+00:00	cbclaw_kg_microbe_sweep LLM	ADDED_SYNONYMS	MAPPED	Added 12 synonyms from kg-microbe P4.4 enrichment: Complexon I, H3nta, Komplexon I, N(CH2-COOH)3, N,N-bis(carboxymethyl)glycine, ... (7 more)
2026-04-19T07:39:23.955331+00:00	audit_mim_merge	MERGED_FROM_DUPLICATES	MAPPED	Absorbed 3 duplicate MIM record(s) into this one: Nitrilotriacetic_Acid_Nta.yaml, Nitrilotriacetic_Acid_2.yaml, Nitrilotriacetic_Acid_3.yaml. Synonyms, curation_history, and occurrence counts were unioned/summed; winner selected by highest occurrence count with preferred_term readability tie-break.
2026-05-01T07:35:35.583817+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:31.685860+00:00	auto_classify_ingredient_type	AUTO_BACKFILL_CHEBI_CHEMISTRY		molecular_formula=C6H9NO6; inchi=InChI=1S/C6H9NO6/c8-4(9)1-7(2-5(10)11)3-6(12)13/h1; smiles=O=C(O)CN(CC(=O)O)CC(=O)O
2026-05-01T08:09:48.085493+00:00	auto_classify_ingredient_type	APPLY_EVIDENCE_PROPOSAL		added pmid=34939907 from propose-evidence batch
2026-05-02T03:12:17.476747+00:00	auto_classify_ingredient_type	AUTO_CLASSIFY_INGREDIENT_TYPE		set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-05-29T23:35:36.112494+00:00	extract_roles_from_synonyms	ANNOTATED		Added media role: MINERAL (confidence: 1.00)
2026-06-09T05:23:46.813676+00:00	correct_stale_ontology_labels.py	CORRECTED		ontology_label 'Nitrilotriacetic acid' -> 'nitrilotriacetic acid': synced to canonical CHEBI label (preferred_term 'Nitrilotriacetic acid' unchanged).
2026-07-20T00:00:00+00:00	migrate_media_roles_to_facets	ANNOTATED		Migrated legacy media_roles to role facets (#128): MINERAL -> physicochemical_roles.CHELATOR
2026-08-27T03:16:39.519633+00:00	refresh_occurrence_statistics	CORRECTED		occurrence_statistics 102/1154 -> 1348/1348 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]