Rifampicin

CHEBI:28077 chemically defined MAPPED CHEBI EXACT_MATCH

Ontology mapping

Primary identifier
CHEBI:28077
Ontology label
rifampicin

Physicochemical roles

Synonyms (8)

SynonymTypeSourceOccurrences
Role: Antimicrobial agent; Properties: Simple component, Defined component, Organic compound RAW_TEXT CultureMech
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate EXACT_SYNONYM kg_microbe
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV EXACT_SYNONYM kg_microbe
RFP EXACT_SYNONYM kg_microbe
Rifampin EXACT_SYNONYM kg_microbe
rifamcin EXACT_SYNONYM kg_microbe
rifampicina EXACT_SYNONYM kg_microbe
rifampicinum EXACT_SYNONYM kg_microbe

Chemical properties

Cas rn
13292-46-1
Data source
PubChem API
Retrieval date
2026-04-05T19:53:49.599972+00:00
Molecular formula
C43H58N4O12
Inchi
InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
Smiles
CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C

Evidence (1)

DATABASE_MATCH via CultureMech

Imported from CultureMech pipeline, quality=DIRECT_MATCH

Occurrence statistics

Total occurrences
3
Distinct media
3

Curation history

TimestampCuratorActionNew statusChanges
2026-03-09T06:54:18.022301+00:00 import_from_culturemech IMPORTED MAPPED Initial import from CultureMech pipeline
2026-04-05T19:53:49.599989+00:00 fetch_cas_rn_from_pubchem ADDED_CAS_RN MAPPED Added CAS-RN:13292-46-1 from PubChem API via name lookup (Rifampicin)
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM ADDED_SYNONYMS MAPPED Added 7 synonyms from kg-microbe P4.4 enrichment: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate, 3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV, RFP, Rifampin, rifamcin, ... (2 more)
2026-05-01T07:35:36.081267+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (CHEBI primary)
2026-05-01T08:08:32.171286+00:00 auto_classify_ingredient_type AUTO_BACKFILL_CHEBI_CHEMISTRY molecular_formula=C43H58N4O12; inchi=InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-; smiles=CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N
2026-05-02T03:12:18.128942+00:00 auto_classify_ingredient_type AUTO_CLASSIFY_INGREDIENT_TYPE set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula))
2026-05-29T23:35:36.112752+00:00 extract_roles_from_synonyms ANNOTATED Added media role: SELECTIVE_AGENT (confidence: 1.00)
2026-06-09T05:23:46.827641+00:00 correct_stale_ontology_labels.py CORRECTED ontology_label 'Rifampicin' -> 'rifampicin': synced to canonical CHEBI label (preferred_term 'Rifampicin' unchanged).
2026-07-20T00:00:00+00:00 migrate_media_roles_to_facets ANNOTATED Migrated legacy media_roles to role facets (#128): SELECTIVE_AGENT -> physicochemical_roles.SELECTIVE_AGENT
2026-08-27T03:16:39.519807+00:00 refresh_occurrence_statistics CORRECTED occurrence_statistics 2/2 -> 3/3 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]