TAPSO

cas:68399-81-5 chemically defined MAPPED CAS FALLBACK_REGISTRY

Ontology mapping

Primary identifier
cas:68399-81-5

Synonyms (2)

SynonymTypeSourceOccurrences
3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]-2-hydroxypropane-1-sulfonic acid EXACT IUPAC
N-[tris(hydroxymethyl)methyl]-3-amino-2-hydroxypropanesulfonic acid EXACT IUPAC

Chemical properties

Cas rn
68399-81-5
Data source
PubChem API
Retrieval date
2026-04-05T19:53:59.993659+00:00

Evidence (1)

DATABASE_MATCH via Edison LITERATURE (PaperQA3) + local CHEBI verification

TAPSO, a Good's zwitterionic buffer, CAS 68399-81-5. Parentless: the local CHEBI build has no TAPSO term and no buffer superclass that denotes it. Note the acronym is a known collision trap -- a naive label search resolves TAPSO to a dermorphin peptide, which is why this is minted rather than matched.

Occurrence statistics

Total occurrences
12
Distinct media
12

Curation history

TimestampCuratorActionNew statusChanges
2026-03-09T06:54:18.022301+00:00 import_from_culturemech IMPORTED MAPPED Initial import from CultureMech pipeline
2026-04-05T19:53:59.993699+00:00 fetch_cas_rn_from_pubchem ADDED_CAS_RN MAPPED Added CAS-RN:68399-81-5 from PubChem API via name lookup (TAPSO)
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM UNMAPPED UNMAPPED Removed incorrect CHEBI:84015 ((1R,2R)-diclocymet, a fungicide metabolite — unrelated compound). TAPSO (CAS 68399-77-9) buffer has no dedicated CHEBI entry; demoted to UNMAPPED pending ontology addition or alternate mapping.
2026-04-18T00:00:00+00:00 cbclaw_kg_microbe_sweep LLM ADDED_SYNONYMS UNMAPPED Added 2 synonyms from kg-microbe P4.4 enrichment: (1R,2R)-diclocymet, (2R)-2-cyano-N-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3,3-dimethylbutanamide
2026-05-11T06:02:00Z mediaingredientmech-agentic-curation LLM CLEANED_INCORRECT_SYNONYMS UNMAPPED Removed kg-microbe diclocymet synonyms that were already documented as unrelated to TAPSO in the 2026-04-18 demotion event.
2026-05-11T08:15:00Z mediaingredientmech-agentic-curation LLM REVIEWED_FALSE_OLS_CANDIDATES UNMAPPED Re-reviewed OAK/OLS exact-audit hits CHEBI:84015 diclocymet and MESH:C047133 dermorphin fragment; kept unmapped because both are unrelated lexical/acronym false positives for TAPSO buffer.
2026-08-06T00:00:00+00:00 edison_literature_identity LLM ANNOTATED Edison LITERATURE (PaperQA3) identity research; report at research/ingredients/TAPSO-edison-literature.md (local artifact — research/ is gitignored, so the findings are quoted here rather than linked). Report verdict: | Recommended value | Evidence assessment | CURIEs discussed: CHEBI:84015, MESH:C047133. Recorded as provenance only — no grounding applied from this run. Edison's recommendations are deliberately conservative, and a plausible identifier promoted by a mechanism that never decided anything is what #203 and #263 exist to undo. Any CURIE above is a curator's to accept or reject.
2026-08-07T00:00:00+00:00 promote_resolved_unmapped PROMOTED_TO_MAPPED MAPPED Promoted TAPSO -> cas:68399-81-5 "TAPSO" (FALLBACK_REGISTRY); mapping_status UNMAPPED -> MAPPED, SSSOM row added.
2026-08-27T03:16:39.518140+00:00 refresh_occurrence_statistics CORRECTED occurrence_statistics 10/10 -> 12/12 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257]