Ontology mapping
- Primary identifier
-
CHEBI:16494 - Ontology label
- lipoic acid
- kg-microbe node
CHEBI:16494
Nutritional roles
- Role
- VITAMIN_SOURCE
- Confidence
- 0.8
- Evidence
- Reference type
- COMPUTATIONAL_PREDICTION
- Reference text
- Inferred from curated media-role name pattern
- Curator note
- Provisional role from a curated name-pattern rule; review recommended.
Synonyms (1)
| Synonym | Type | Source | Occurrences |
|---|---|---|---|
| Role: Growth factor; Properties: Organic compound, Defined component, Simple component | RAW_TEXT | CultureMech |
Rejected enrichment labels (11)
Provenance-only candidates: these are not synonyms and do not resolve to this record.
| Rejected label | Disposition | Source | Occurrences |
|---|---|---|---|
| (+)-alpha-Lipoic acid | REJECTED_LABEL | kg_microbe | |
| (R)-(+)-Lipoate | REJECTED_LABEL | kg_microbe | |
| (R)-(+)-lipoic acid | REJECTED_LABEL | kg_microbe | |
| (R)-1,2-Dithiolane-3-pentanoic acid | REJECTED_LABEL | kg_microbe | |
| (R)-1,2-dithiolane-3-valeric acid | REJECTED_LABEL | kg_microbe | |
| (R)-6,8-thioctic acid | REJECTED_LABEL | kg_microbe | |
| 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid | REJECTED_LABEL | kg_microbe | |
| R-(+)-Lipoic acid | REJECTED_LABEL | kg_microbe | |
| R-LA | REJECTED_LABEL | kg_microbe | |
| RLA | REJECTED_LABEL | kg_microbe | |
| Thioctic acid d-form | REJECTED_LABEL | kg_microbe |
Evidence (1)
CURATOR_JUDGMENT
via MIM curation (#454)
The source label names generic or racemic lipoic/thioctic acid. No source occurrence asserts an R- or S-only enantiomer, so CHEBI:16494 is the supported ChEBI target.
Occurrence statistics
- Total occurrences
- 0
- Distinct media
- 0
Curation history
| Timestamp | Curator | Action | New status | Changes |
|---|---|---|---|---|
| 2026-03-09T06:54:18.022301+00:00 | import_from_culturemech | IMPORTED | MAPPED | Initial import from CultureMech pipeline |
| 2026-04-05T19:54:04.445666+00:00 | fetch_cas_rn_from_pubchem | ADDED_CAS_RN | MAPPED | Added CAS-RN:1077-28-7 from PubChem API via name lookup (Thioctic acid) |
| 2026-04-05T21:48:45.892059+00:00 | fetch_cas_rn_from_culturebot_csv | ADDED_CAS_RN | MAPPED | Added CAS-RN:1077-28-7 from CultureBotHT compounds_to_cas.csv (matched: Thioctic Acid) |
| 2026-04-18T00:00:00+00:00 | cbclaw_kg_microbe_sweep LLM | ADDED_SYNONYMS | MAPPED | Added 11 synonyms from kg-microbe P4.4 enrichment: (+)-alpha-Lipoic acid, (R)-(+)-Lipoate, (R)-(+)-lipoic acid, (R)-1,2-Dithiolane-3-pentanoic acid, (R)-1,2-dithiolane-3-valeric acid, ... (6 more) |
| 2026-04-19T07:39:23.955331+00:00 | audit_mim_merge | MERGED_FROM_DUPLICATES | MAPPED | Absorbed 1 duplicate MIM record(s) into this one: Thioctic_Acid_2.yaml. Synonyms, curation_history, and occurrence counts were unioned/summed; winner selected by highest occurrence count with preferred_term readability tie-break. |
| 2026-05-01T07:35:36.629878+00:00 | auto_classify_ingredient_type | AUTO_CLASSIFY_INGREDIENT_TYPE | set ingredient_type=SINGLE_INGREDIENT (CHEBI primary) | |
| 2026-05-01T08:08:32.705802+00:00 | auto_classify_ingredient_type | AUTO_BACKFILL_CHEBI_CHEMISTRY | molecular_formula=C8H14O2S2; inchi=InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h; smiles=O=C(O)CCCC[C@@H]1CCSS1 | |
| 2026-05-02T03:12:18.864694+00:00 | auto_classify_ingredient_type | AUTO_CLASSIFY_INGREDIENT_TYPE | set ingredient_type=SINGLE_INGREDIENT (chemical structure populated (molecular_formula)) | |
| 2026-06-03T02:06:01.752469+00:00 | infer_roles_from_name_lists | ANNOTATED | Added media role: VITAMIN_SOURCE (confidence: 0.80) | |
| 2026-07-20T00:00:00+00:00 | migrate_media_roles_to_facets | ANNOTATED | Migrated legacy media_roles to role facets (#128): VITAMIN_SOURCE -> nutritional_roles.VITAMIN_SOURCE | |
| 2026-08-27T03:16:39.519965+00:00 | refresh_occurrence_statistics | CORRECTED | occurrence_statistics 30/30 -> 36/36 (media_count/total_occurrences), derived from distinct CultureMech recipe ids in the #337 occurrence table. The prior values came from the importer retired in #453, whose media_count counted a list truncated to 50 examples (#449). [source=ingredient_occurrences.tsv culturemech_rev=15a4da5c08 rows=194137 distinct_recipes=15257] | |
| 2026-09-11T14:49:05.979520+00:00 | fix_lipoic_stereochemistry | MERGED_INTO | REJECTED | Merged into CHEBI:16494 '(DL)-alpha-Lipoic acid'; the old CHEBI:30314 target was an unsupported enantiomer-specific grounding. Occurrences were transferred to the generic lipoic acid record and SSSOM rows were dropped (#454), and 11 R/S-only target synonym(s) were retained as REJECTED_LABEL provenance (#454/#634). |