Esculin Hydrolysate

Ontology mapping

Primary identifier: UNMAPPED_0688
Notes: Imported from microbedecoder (source_id=kgmicrobe.trait:esculin_hydrolysate); no CAS-RN or CHEBI/NCIT match. Curator review needed. Retired as an ingredient record (#213/#308): names the esculin-hydrolysis TEST, not a substance. The API 20 NE reading table lists esculin and ferric citrate as the cupule's active ingredients and hydrolysis as the reaction; MicrO models it as MICRO:0000722 'esculin ferric citrate assay'. The reagents are already records: `Esculin Monohydrate` (CHEBI:4853) and `Esculin Ferric Citrate`; the released aglycone esculetin is CHEBI:490095. Not mapped, because every substrate CURIE it could be grounded to is already the primary key of a live record — in MIM the identifier IS the ontology CURIE, so a mapping here would mint a duplicate rather than add coverage. No synonym is folded onto those records either: this label names a reaction or a splice, not the substance, and asserting the synonymy would make label_index resolve it to something it does not denote.

Synonyms (1)

Synonym	Type	Source	Occurrences
Esculin Hydrolysate	RAW_TEXT	microbedecoder

Occurrence statistics

Total occurrences

Distinct media

Source occurrences

Source
microbedecoder
Count
6
Source columns
BacDive_Metabolite_utilization

Curation history

Timestamp	Curator	Action	New status	Changes
2026-08-04T02:54:09.684805+00:00	audit_import_ingredients[microbedecoder]	CREATED_AS_UNMAPPED	UNMAPPED	Imported from microbedecoder (source_id=kgmicrobe.trait:esculin_hydrolysate); no CAS-RN or CHEBI/NCIT match. Curator review needed.
2026-08-06T00:00:00+00:00	issue_213_residual_triage LLM	FLAGGED_NEEDS_EXPERT	NEEDS_EXPERT	Not an ingredient: an assay reaction product rather than a medium component. Same scope question as #209. Searched CHEBI, NCIT, FOODON, ENVO, MeSH, BTO and UBERON by label and synonym with normalisation, plus exact queries across all of live OLS4.
2026-08-06T00:00:00+00:00	edison_literature_identity LLM	ANNOTATED		Edison LITERATURE (PaperQA3) identity research; report at research/ingredients/Esculin_Hydrolysate-edison-literature.md (local artifact — research/ is gitignored, so the findings are quoted here rather than linked). Report verdict: ## Executive recommendation — Retain `UNMAPPED`, but annotate the record as a probable non-ingredient phenotype/reaction label. The retrieved literature supports esculin hydrolysis as a microbiological biochemical test: esculin is the supplied substrate, hydrolysis generates glucose and a coumarin aglycone, and ferric ions produce the black indicator complex. It does not support “Escul No ontology CURIE was proposed. Recorded as provenance only — no grounding applied from this run. Edison's recommendations are deliberately conservative, and a plausible identifier promoted by a mechanism that never decided anything is what #203 and #263 exist to undo. Any CURIE above is a curator's to accept or reject.
2026-08-15T00:00:00+00:00	retire_assay_labels	RETIRED_NOT_AN_INGREDIENT	REJECTED	Retired as an ingredient record (#213/#308): names the esculin-hydrolysis TEST, not a substance. The API 20 NE reading table lists esculin and ferric citrate as the cupule's active ingredients and hydrolysis as the reaction; MicrO models it as MICRO:0000722 'esculin ferric citrate assay'. The reagents are already records: `Esculin Monohydrate` (CHEBI:4853) and `Esculin Ferric Citrate`; the released aglycone esculetin is CHEBI:490095. Not mapped, because every substrate CURIE it could be grounded to is already the primary key of a live record — in MIM the identifier IS the ontology CURIE, so a mapping here would mint a duplicate rather than add coverage. No synonym is folded onto those records either: this label names a reaction or a splice, not the substance, and asserting the synonymy would make label_index resolve it to something it does not denote.