fusaric acid

naturalproductmech:mibig-a6104a2a79 MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	DGMPVYSXXIOGJY-UHFFFAOYSA-N
SMILES	CCCCC1=CN=C(C=C1)C(=O)O
Stereochemistry	fully defined
Cross-references	pubchem:3442

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Fusarium verticillioides 7600 NCBITaxon:334819	SOURCE_ASSERTION	mibig:BGC0001190	DOI:10.1080/01480545.2018.1499772

Occurrences 7

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Fusarium verticillioides NCBITaxon:117187	LOTUS	DOI:10.1094/MPMI-09-14-0264-R
Fusarium solani NCBITaxon:169388	LOTUS	DOI:10.1016/0031-9422(77)80027-7
Fusarium nygamai NCBITaxon:42673	LOTUS	DOI:10.1016/0031-9422(95)00716-4
Fusarium fujikuroi NCBITaxon:5127	LOTUS	DOI:10.1007/BF01146164
Fusarium fujikuroi NCBITaxon:5127	LOTUS	DOI:10.1094/MPMI-09-14-0264-R
Fusarium oxysporum NCBITaxon:5507	LOTUS	DOI:10.1016/S0040-4020(01)88352-6
Fusarium oxysporum NCBITaxon:5507	LOTUS	DOI:10.1080/14786419.2017.1415897

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001190	Fusarium verticillioides 7600 NCBITaxon:334819	CLUSTER_UNSTATED	genbank:CM000580.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech (fusaric acid) ↗ MediaIngredientMech (naturalproductmech:mibig-a6104a2a79) ↗ TaxonMech: Fusarium verticillioides 7600 (NCBITaxon:334819) ↗ PathwayMech (mibig:BGC0001190) ↗

Provenance

Source concept	Source	Version
BGC0001190	MIBIG	3

This page is generated from data/natural_products/alkaloids/fusaric-acid.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.	OTHER 33.4983 uM; NOT_DETERMINED	Not recorded	pubchem.aid:624296 assay A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. evidence reference pubchem.aid:624296 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624296, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 33.4983 units uM
A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.	OTHER 2.8184 uM; NOT_DETERMINED	Not recorded	pubchem.aid:624297 assay A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. evidence reference pubchem.aid:624297 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624297, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 2.8184 units uM
Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV	OTHER 10 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1708 assay Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV evidence reference pubchem.aid:1708 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1708, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAA60529 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 10.0 units uM
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay	OTHER 2.6837 uM; INACTIVE	Not recorded	pubchem.aid:1645841 assay Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay evidence reference pubchem.aid:1645841 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645841, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession ABI96208 was left ungrounded because PubChem did not provide a UniProtKB accession. call INACTIVE measurement type OTHER value 2.6837 units uM
Nrf2 qHTS screen for inhibitors: Validation	OTHER 20.5962 uM; NOT_DETERMINED	Not recorded	pubchem.aid:493153 assay Nrf2 qHTS screen for inhibitors: Validation evidence reference pubchem.aid:493153 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 493153, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 20.5962 units uM
Nrf2 qHTS screen for inhibitors: Validation	OTHER 20.5962 uM; NOT_DETERMINED	Not recorded	pubchem.aid:493153 assay Nrf2 qHTS screen for inhibitors: Validation evidence reference pubchem.aid:493153 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 493153, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001138884 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 20.5962 units uM
P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	OTHER 16.3601 uM; NOT_DETERMINED	Not recorded	PMID:31515284 assay P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen evidence reference PMID:31515284 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1346987, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 16.3601 units uM
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation	OTHER 18.526 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504832 assay Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation evidence reference pubchem.aid:504832 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504832, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 18.526 units uM
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation	OTHER 5.2213 uM; INACTIVE	Not recorded	pubchem.aid:504834 assay Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation evidence reference pubchem.aid:504834 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504834, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call INACTIVE measurement type OTHER value 5.2213 units uM
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation	OTHER 4.7755 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504834 assay Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation evidence reference pubchem.aid:504834 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504834, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 4.7755 units uM
Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity	OTHER 0.38 uM; INACTIVE	Not recorded	pubchem.aid:651823 assay Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity evidence reference pubchem.aid:651823 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 651823, deposited by Broad Institute; assay type Confirmatory. Source endpoint: Max_Activity_Concentration_uM. Target accession NP_987096 was left ungrounded because PubChem did not provide a UniProtKB accession. call INACTIVE measurement type OTHER value 0.38 units uM
VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity	OTHER 8.9125 uM; ACTIVE	Not recorded	pubchem.aid:2546 assay VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity evidence reference pubchem.aid:2546 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2546, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_035411 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 8.9125 units uM activity class ENZYME_INHIBITOR
VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity	OTHER 7.0795 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2546 assay VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity evidence reference pubchem.aid:2546 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2546, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_035411 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 7.0795 units uM
VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity	OTHER 25.1189 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2546 assay VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity evidence reference pubchem.aid:2546 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2546, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_035411 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 25.1189 units uM
qHTS Assay for Activators of Cytochrome P450 3A4	OTHER 25.1189 uM; INACTIVE	Not recorded	pubchem.aid:885 assay qHTS Assay for Activators of Cytochrome P450 3A4 evidence reference pubchem.aid:885 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 885, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_059488 was left ungrounded because PubChem did not provide a UniProtKB accession. call INACTIVE measurement type OTHER value 25.1189 units uM
qHTS Assay for Activators of Human Muscle Pyruvate Kinase	OTHER 0.2512 uM; INACTIVE	Not recorded	pubchem.aid:954 assay qHTS Assay for Activators of Human Muscle Pyruvate Kinase evidence reference pubchem.aid:954 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 954, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_872270 was left ungrounded because PubChem did not provide a UniProtKB accession. call INACTIVE measurement type OTHER value 0.2512 units uM
qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor	OTHER 25.1189 uM; NOT_DETERMINED	Not recorded	pubchem.aid:926 assay qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor evidence reference pubchem.aid:926 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 926, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAR07906 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 25.1189 units uM
qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293	OTHER 25.1189 uM; NOT_DETERMINED	Not recorded	pubchem.aid:938 assay qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 evidence reference pubchem.aid:938 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 938, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAR07906 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 25.1189 units uM
qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response	OTHER 0.1413 uM; NOT_DETERMINED	Not recorded	pubchem.aid:943 assay qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response evidence reference pubchem.aid:943 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 943, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_542951 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 0.1413 units uM
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation	OTHER 6.3096 uM; ACTIVE	Not recorded	pubchem.aid:504374 assay qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation evidence reference pubchem.aid:504374 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504374, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_001001890 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 6.3096 units uM
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation	OTHER 6.3096 uM; ACTIVE	Not recorded	pubchem.aid:504374 assay qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation evidence reference pubchem.aid:504374 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504374, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_001746 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 6.3096 units uM
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation	OTHER 35.4813 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504370 assay qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation evidence reference pubchem.aid:504370 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504370, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001001890 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 35.4813 units uM
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation	OTHER 35.4813 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504370 assay qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation evidence reference pubchem.aid:504370 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504370, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001746 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 35.4813 units uM
qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway	OTHER 15.8489 uM; NOT_DETERMINED	Not recorded	pubchem.aid:914 assay qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway evidence reference pubchem.aid:914 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 914, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAP88778 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 15.8489 units uM
qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway	OTHER 2.5119 uM; NOT_DETERMINED	Not recorded	pubchem.aid:914 assay qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway evidence reference pubchem.aid:914 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 914, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAP88778 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 2.5119 units uM notes 73 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.