fusaric acid
naturalproductmech:mibig-a6104a2a79 MINTED SEEDED enzyme inhibitor
Structure
| Standard InChIKey | DGMPVYSXXIOGJY-UHFFFAOYSA-N |
|---|---|
| SMILES | CCCCC1=CN=C(C=C1)C(=O)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:3442 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Fusarium verticillioides 7600 NCBITaxon:334819 |
SOURCE_ASSERTION | mibig:BGC0001190 | DOI:10.1080/01480545.2018.1499772 |
Occurrences 7
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Fusarium verticillioides NCBITaxon:117187 |
LOTUS | DOI:10.1094/MPMI-09-14-0264-R |
| Fusarium solani NCBITaxon:169388 |
LOTUS | DOI:10.1016/0031-9422(77)80027-7 |
| Fusarium nygamai NCBITaxon:42673 |
LOTUS | DOI:10.1016/0031-9422(95)00716-4 |
| Fusarium fujikuroi NCBITaxon:5127 |
LOTUS | DOI:10.1007/BF01146164 |
| Fusarium fujikuroi NCBITaxon:5127 |
LOTUS | DOI:10.1094/MPMI-09-14-0264-R |
| Fusarium oxysporum NCBITaxon:5507 |
LOTUS | DOI:10.1016/S0040-4020(01)88352-6 |
| Fusarium oxysporum NCBITaxon:5507 |
LOTUS | DOI:10.1080/14786419.2017.1415897 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001190 | Fusarium verticillioides 7600 NCBITaxon:334819 |
CLUSTER_UNSTATED | genbank:CM000580.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 25
| Assay | Result | Reference |
|---|---|---|
| A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. | 33.4983 uM | pubchem.aid:624296 |
| A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. | 2.8184 uM | pubchem.aid:624297 |
| Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV | 10 uM | pubchem.aid:1708 |
| Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay | 2.6837 uM | pubchem.aid:1645841 |
| Nrf2 qHTS screen for inhibitors: Validation | 20.5962 uM | pubchem.aid:493153 |
| Nrf2 qHTS screen for inhibitors: Validation | 20.5962 uM | pubchem.aid:493153 |
| P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 16.3601 uM | PMID:31515284 |
| Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation | 18.526 uM | pubchem.aid:504832 |
| Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation | 5.2213 uM | pubchem.aid:504834 |
| Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation | 4.7755 uM | pubchem.aid:504834 |
| Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity | 0.38 uM | pubchem.aid:651823 |
| VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity | 8.9125 uM | pubchem.aid:2546 |
| VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity | 7.0795 uM | pubchem.aid:2546 |
| VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity | 25.1189 uM | pubchem.aid:2546 |
| qHTS Assay for Activators of Cytochrome P450 3A4 | 25.1189 uM | pubchem.aid:885 |
| qHTS Assay for Activators of Human Muscle Pyruvate Kinase | 0.2512 uM | pubchem.aid:954 |
| qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor | 25.1189 uM | pubchem.aid:926 |
| qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 | 25.1189 uM | pubchem.aid:938 |
| qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response | 0.1413 uM | pubchem.aid:943 |
| qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation | 6.3096 uM | pubchem.aid:504374 |
| qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation | 6.3096 uM | pubchem.aid:504374 |
| qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation | 35.4813 uM | pubchem.aid:504370 |
| qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation | 35.4813 uM | pubchem.aid:504370 |
| qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway | 15.8489 uM | pubchem.aid:914 |
| qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway | 2.5119 uM | pubchem.aid:914 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001190 | MIBIG | 3 |
This page is generated from data/natural_products/alkaloids/fusaric-acid.yaml, which is generated from the committed inventories. Neither is edited by hand.