(−)-noscapine

CHEBI:73237 EXACT SEEDED

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from plants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects.

Structure

Standard InChIKey	AKNNEGZIBPJZJG-MSOLQXFVSA-N
SMILES	CN1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3
Stereochemistry	fully defined
Cross-references	pubchem:275196

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Papaver somniferum NCBITaxon:3469	SOURCE_ASSERTION	mibig:BGC0001325	DOI:10.1371/journal.pone.0017733

Occurrences 25

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Corydalis heterocarpa var. japonica NCBITaxon:1030657	LOTUS	DOI:10.1002/ARDP.19873200805
Papaver pseudo-orientale NCBITaxon:215228	LOTUS	DOI:10.1016/S0031-9422(00)81705-7
Papaver setigerum NCBITaxon:215229	LOTUS	DOI:10.1055/S-2007-969106
Papaver orientale NCBITaxon:22694	LOTUS	DOI:10.1016/S0031-9422(00)81705-7
Papaver fugax NCBITaxon:3117443	LOTUS	DOI:10.1016/S0031-9422(00)81705-7
Papaver rhoeas NCBITaxon:33128	LOTUS	DOI:10.1055/S-2006-960934
Papaver oreophilum NCBITaxon:3736021	LOTUS	DOI:10.1021/NP070099O
Roemeria carica NCBITaxon:3736784	LOTUS	DOI:10.3987/R-1986-05-1227
Corydalis ochotensis NCBITaxon:38907	LOTUS	DOI:10.1002/ARDP.19873200805
Corydalis solida NCBITaxon:38914	LOTUS	DOI:10.1139/V69-178
Corydalis ophiocarpa NCBITaxon:38929	LOTUS	DOI:10.1002/ARDP.19873200805
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1002/PCA.2800020205
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1016/0305-1978(88)90092-0
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1016/0379-0738(94)90219-4
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1016/0731-7085(95)01574-4
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1016/S0021-9673(00)94605-3
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1016/S0031-9422(00)88047-4
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1016/S0031-9422(99)00420-3
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1055/S-2006-957966
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1055/S-2006-959739
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1055/S-2007-969106
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1055/S-2007-969109
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1073/PNAS.95.4.1601
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1126/SCIENCE.1220757
Papaver somniferum NCBITaxon:3469	LOTUS	DOI:10.1515/ZNC-1984-9-1004

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001325	Papaver somniferum NCBITaxon:3469	CLUSTER_UNSTATED	genbank:MIBIG.BGC0001325.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Biosynthesis curated

Written by a curator with claim-level evidence on each step; not derived from a source. This is what the rest of the record exists to support.

Step	Enzyme	Reaction	Substrate → product	Evidence
1	PsSDR1 noscapine synthase UniProtKB:I3PLR3	RHEA:57404	CHEBI:141667 + CHEBI:57540 → CHEBI:73237 + CHEBI:57945 + CHEBI:15378	DOI:10.1038/ncomms12137

Step 1: Papaver somniferum PsSDR1 oxidizes narcotine hemiacetal with NAD(+) to noscapine, NADH and H(+). This terminal SDR1 step records RHEA:57404 and leaves the upstream PsMT2/PsMT3 and PsCXE1 formation of narcotine hemiacetal unexpanded.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 3 nodes, 2 edges

Papaver somniferum PsSDR1 oxidizes narcotine hemiacetal to noscapine in the late noscapine biosynthetic pathway.

Subject	Predicate	Object	Notes	Evidence
narcotine hemiacetal	is dehydrogenated by	PsSDR1	RHEA:57404 places narcotine hemiacetal on the substrate side of the SDR1/NAD(+) noscapine synthase reaction.	DOI:10.1038/ncomms12137 https://www.uniprot.org/uniprotkb/I3PLR3 https://www.rhea-db.org/rhea/57404 reference DOI:10.1038/ncomms12137 evidence type PRIMARY_EXPERIMENT snippet Reconstituting PsCXE1 and PsSDR1 activities notes Li and Smolke reconstituted Papaver somniferum PsSDR1 in engineered Saccharomyces cerevisiae strains that traverse the late noscapine pathway and form noscapine-pathway intermediates. reference https://www.uniprot.org/uniprotkb/I3PLR3 evidence type DATABASE_ASSERTION retrieved on 2026-09-30 notes Reviewed UniProtKB:I3PLR3 is the 348 aa Papaver somniferum SDR1 noscapine synthase, cross-references EMBL JQ659007 protein AFB74619.1, annotates RHEA:57404 / left-to-right RHEA:57405, and cites DOI:10.1038/ncomms12137 for catalytic activity. reference https://www.rhea-db.org/rhea/57404 evidence type DATABASE_ASSERTION retrieved on 2026-09-30 notes RHEA:57404 is the narcotine hemiacetal plus NAD(+) to noscapine plus NADH plus H(+) reaction; Rhea maps this master reaction and the RHEA:57405 left-to-right direction to UniProtKB:I3PLR3 in Swiss-Prot.
PsSDR1	forms	noscapine	RHEA:57404 places noscapine on the product side of the SDR1/NAD(+) noscapine synthase reaction.	DOI:10.1038/ncomms12137 https://www.uniprot.org/uniprotkb/I3PLR3 https://www.rhea-db.org/rhea/57404 reference DOI:10.1038/ncomms12137 evidence type PRIMARY_EXPERIMENT snippet Reconstituting PsCXE1 and PsSDR1 activities notes Li and Smolke reconstituted Papaver somniferum PsSDR1 in engineered Saccharomyces cerevisiae strains that traverse the late noscapine pathway and form noscapine-pathway intermediates. reference https://www.uniprot.org/uniprotkb/I3PLR3 evidence type DATABASE_ASSERTION retrieved on 2026-09-30 notes Reviewed UniProtKB:I3PLR3 is the 348 aa Papaver somniferum SDR1 noscapine synthase, cross-references EMBL JQ659007 protein AFB74619.1, annotates RHEA:57404 / left-to-right RHEA:57405, and cites DOI:10.1038/ncomms12137 for catalytic activity. reference https://www.rhea-db.org/rhea/57404 evidence type DATABASE_ASSERTION retrieved on 2026-09-30 notes RHEA:57404 is the narcotine hemiacetal plus NAD(+) to noscapine plus NADH plus H(+) reaction; Rhea maps this master reaction and the RHEA:57405 left-to-right direction to UniProtKB:I3PLR3 in Swiss-Prot.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech ((−)-noscapine) ↗ MediaIngredientMech (CHEBI:73237) ↗ TaxonMech: Papaver somniferum (NCBITaxon:3469) ↗ PathwayMech (mibig:BGC0001325) ↗

Provenance

Source concept	Source	Version
BGC0001325	MIBIG	3
CHEBI:73237	CHEBI	3-star

This page is generated from data/natural_products/alkaloids/noscapine.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 32 hour	OTHER 26.8325 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1224883 assay A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 32 hour evidence reference pubchem.aid:1224883 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1224883, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 26.8325 units uM
A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 40 hour	OTHER 26.8325 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1224879 assay A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 40 hour evidence reference pubchem.aid:1224879 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1224879, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 26.8325 units uM
A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.	OTHER 29.0929 uM; NOT_DETERMINED	Not recorded	pubchem.aid:624297 assay A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. evidence reference pubchem.aid:624297 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624297, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 29.0929 units uM
A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.	OTHER 23.1093 uM; NOT_DETERMINED	Not recorded	pubchem.aid:624297 assay A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. evidence reference pubchem.aid:624297 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624297, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 23.1093 units uM
Caspase-3/7 induction in CHO-K1 cells by small molecules, qHTS cell viability counter screen	OTHER 13.3332 uM; ACTIVE	Not recorded	pubchem.aid:1346979 assay Caspase-3/7 induction in CHO-K1 cells by small molecules, qHTS cell viability counter screen evidence reference pubchem.aid:1346979 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1346979, deposited by 824; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 13.3332 units uM
Caspase-3/7 induction in HepG2 cells by small molecules, qHTS cell viability counter screen	OTHER 14.9601 uM; ACTIVE	Not recorded	pubchem.aid:1346981 assay Caspase-3/7 induction in HepG2 cells by small molecules, qHTS cell viability counter screen evidence reference pubchem.aid:1346981 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1346981, deposited by 824; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 14.9601 units uM
Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R	OTHER 29.0929 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1963990 assay Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R evidence reference pubchem.aid:1963990 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963990, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 29.0929 units uM
Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13	OTHER 23.1093 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1963989 assay Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 evidence reference pubchem.aid:1963989 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963989, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 23.1093 units uM
Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line 8505C	OTHER 23.0153 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202553 assay Cellular viability qHTS for anaplastic thyroid cancer (ATC) cell line 8505C evidence reference pubchem.aid:2202553 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202553, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 23.0153 units uM
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay	OTHER 1.3803 uM; ACTIVE	Not recorded	pubchem.aid:1671197 assay Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671197 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671197, deposited by 824; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 1.3803 units uM
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay	OTHER 1.3803 uM; ACTIVE	Not recorded	pubchem.aid:1671197 assay Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671197 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671197, deposited by 824; assay type Confirmatory. Source endpoint: Potency. Target accession AAV41877 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 1.3803 units uM
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay	OTHER 0.8709 uM; ACTIVE	Not recorded	pubchem.aid:1671198 assay Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671198 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671198, deposited by 824; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 0.8709 units uM
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay	OTHER 0.8709 uM; ACTIVE	Not recorded	pubchem.aid:1671198 assay Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671198 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671198, deposited by 824; assay type Confirmatory. Source endpoint: Potency. Target accession AGS09764 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 0.8709 units uM
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay	OTHER 10.964 uM; ACTIVE	Not recorded	pubchem.aid:1671196 assay Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671196 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671196, deposited by 824; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 10.964 units uM
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay	OTHER 10.964 uM; ACTIVE	Not recorded	pubchem.aid:1671196 assay Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671196 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671196, deposited by 824; assay type Confirmatory. Source endpoint: Potency. Target accession ANW61984 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 10.964 units uM
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay	OTHER 0.6918 uM; ACTIVE	Not recorded	pubchem.aid:1671201 assay Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671201 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671201, deposited by 824; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 0.6918 units uM
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay	OTHER 0.6918 uM; ACTIVE	Not recorded	pubchem.aid:1671201 assay Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay evidence reference pubchem.aid:1671201 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671201, deposited by 824; assay type Confirmatory. Source endpoint: Potency. Target accession ABI96208 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 0.6918 units uM
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay	OTHER 0.1096 uM; ACTIVE	Not recorded	pubchem.aid:1645842 assay Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay evidence reference pubchem.aid:1645842 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645842, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession QLI62812 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 0.1096 units uM
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: luciferase cell-based qHTS assay	OTHER 4.8975 uM; ACTIVE	Not recorded	pubchem.aid:1645840 assay Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: luciferase cell-based qHTS assay evidence reference pubchem.aid:1645840 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645840, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession ANW61984 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 4.8975 units uM
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay	OTHER 0.4365 uM; ACTIVE	Not recorded	pubchem.aid:1645841 assay Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay evidence reference pubchem.aid:1645841 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645841, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession ABI96208 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 0.4365 units uM
Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay	OTHER 0.389 uM; ACTIVE	Not recorded	pubchem.aid:1963596 assay Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay evidence reference pubchem.aid:1963596 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963596, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 0.389 units uM
Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay	OTHER 0.389 uM; ACTIVE	Not recorded	pubchem.aid:1963596 assay Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay evidence reference pubchem.aid:1963596 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963596, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_000756 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 0.389 units uM
GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression	OTHER 5.6234 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1671193 assay GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression evidence reference pubchem.aid:1671193 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671193, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 5.6234 units uM
Human pregnane X receptor (PXR) activation by small molecules, qHTS assay	OTHER 22.3872 uM; ACTIVE	Not recorded	pubchem.aid:1346985 assay Human pregnane X receptor (PXR) activation by small molecules, qHTS assay evidence reference pubchem.aid:1346985 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1346985, deposited by 824; assay type Confirmatory. Source endpoint: Potency. Target accession ADZ17384 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 22.3872 units uM
Human pregnane X receptor (PXR) small molecule agonists, qHTS assay	OTHER 11.8832 uM; ACTIVE	Not recorded	pubchem.aid:1346982 assay Human pregnane X receptor (PXR) small molecule agonists, qHTS assay evidence reference pubchem.aid:1346982 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1346982, deposited by 824; assay type Confirmatory. Source endpoint: Potency. Target accession ADZ17384 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 11.8832 units uM notes 119 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.